• br Material and methods br Results br Discussion Neurosteroi

  2022-05-19

  

  Material and methods Results Discussion Neurosteroids capable of blocking the NMDAR channel attract a lot of attention as possible therapeutic agents for the treatment of neurodegenerative diseases. A large number of new CC-223 with different structures have been synthesized in order to cr

• br Spatial working memory is

  2022-05-19

  

  Spatial working memory is GluR-A-dependent The radial maze task also allowed us to study hippocampus-dependent spatial working memory. On spatial working memory tasks, the correct spatial response that the animal must make varies from trial to trial and is dependent on some conditional, trial-spe

• br Conclusion In conclusion SHP was demonstrated as a potent

  2022-05-19

  

  Conclusion In conclusion, SHP289-04 was demonstrated as a potent glucokinase activator. It could normalize the blood glucose level and lipid level in spontaneous type 2 diabetes model KKAy mice. At the same time, it ameliorated the function of islets and liver in KKAy mice. It had been proved to

• Medulloblastoma predominantly occurs in infants and children

  2022-05-19

  

  Medulloblastoma predominantly occurs in infants and children, and is the most-common type of paediatric malignant Isoprenaline HCl tumour, accounting for about 20% of all childhood brain tumors [63]. According to cancer genomics, medulloblastoma consists of at least 4 distinct subgroups: Hh driven,

• Another key component of proper DA cell physiology

  2022-05-19

  

  Another key component of proper DA cell physiology is the basal firing activity of SN DA neurons, which maintains extracellular levels of dopamine in the dorsal striatum that are essential for voluntary movement [106]. Changes in SN DA neuron activity directly impacts the amount of dopamine released

• Y 134 br Role of BKCa in Cardiovascular System br Perspectiv

  2022-05-19

  

  Role of BKCa in Cardiovascular System Perspective for BKCa Channels as Potential Target for Cardiovascular Diseases The intermediate conductance Ca-activated K+ channels (IKCa; KCa3.1, also known as SK4, IK, IKCa1, SMIK) were first discovered in erythrocytes by Gardos (1958) and then also fo

• As many of the above studies highlight several

  2022-05-19

  

  As many of the above studies highlight, several decades of research on Cx43 has revealed that many of these functional roles are attributed to the C-terminal domain (CT) of this protein which cannot be explained by the formation and existence of intercellular channels. Recent findings on the existen

• Ketoprofen The NVC response in the

  2022-05-19

  

  The NVC response in the diseased or aging Ketoprofen may be altered, including changes in both the chemical mediators of NVC, ion channel behaviour, and the dynamics of the vascular system. For example, in Alzheimer’s disease the production of NO is shown to be inhibited (Lourenço et al., 2014), hyp

• Recent studies have elucidated a profound role for FFA in

  2022-05-19

  

  Recent studies have elucidated a profound role for FFA4 in modulation of metabolism and energy utilization as well as endocrine and immune function, and as a consequence, have thrust FFA4 to the forefront of drug discovery efforts. For example, activation of FFA4 by fatty GSK-923295 or synthetic li

• Both anxiety like behavior and sucrose preference

  2022-05-19

  

  Both anxiety-like behavior and sucrose preference/intake were reduced in GPR40/FFAR1 KO male mice, while social behavior was normal in KO mice. These findings indicate that brain GPR40/FFAR1 is involved in the modulation of anxiety- and depression-like behavior in rodents. Previous studies have demo

• FSLLRY-NH2 Almost all of the series and compounds exhibited

  2022-05-19

  

  Almost all of the series and compounds exhibited higher activities compared with the compounds in the other series. In these series, the tetrazole group was directly linked to a nitrogen atom of the amide group at the C-28 position, and the C-3 hydroxy group was either unmodified, oxidized, esteri

• Several recent studies have linked clock function with the c

  2022-05-19

  

  Several recent studies have linked clock function with the cell cycle and reported that clock components, such as PER1, PER2, BMAL1, and CRY1/2 decrease cell proliferation or improve the action of anti-cancer drugs in different cancer cell lines. Moreover, certain types of human cancer show an alter

• Although no data exist on

  2022-05-19

  

  Although no data exist on Ptc52 gene pp2 in other plant species, the expression pattern presented in this study shows perceptibly low levels of transcript accumulation in tomato seeds and roots, low levels in the stem, flower and green fruit, and high levels in the leaves. This coincides with the e

• Several plant derived molecules such as resveratrol curcumin

  2022-05-19

  

  Several plant-derived molecules such as resveratrol, curcumin, zerumbone, and physalin B have been reported as modulators of Hh/Gli signaling pathway (Hosoya et al., 2008, Mohapatra et al., 2015). Our previous studies have demonstrated that a sesquiterpene lactone and diarylheptanoids from Siegesbec

• how to calculate dilution Introduction Hepatocellular carcin

  2022-05-18

  

  Introduction Hepatocellular carcinoma (HCC) is the fifth most lethal malignant tumor worldwide and is the second leading cause of cancer-related death [1]. For HCC patients, how to calculate dilution virus (HBV) infection is the important causative risk factor in Asia-Pacific regions [[2], [3], [4

14913 records 385/995 page Previous Next First page 上5页 381382383384385 下5页 Last page