• Z-IETD-FMK formula br Summary and perspectives In recent dec

  2019-08-17

  

  Summary and perspectives In recent decades, enormous advances have been achieved in the development of enzyme-activatable imaging probes, enabling the accurate detection of enzyme activity in vivo to better understand the biological function of enzymes in disease processes. Activatable probes are

• br Results br Discussion Taking advantage of the

  2019-08-17

  

  Results Discussion Taking advantage of the highly specific protein–protein interactions among cognate Parthenolide reviews that mediate SUMO conjugation to substrates, we have developed a novel strategy for achieving inhibition of SUMO conjugation in vivo based on disruption of SUMO E1–E2 inte

• The UPP broadly involves proteolysis in biochemical

  2019-08-17

  

  The UPP broadly involves proteolysis in biochemical processes and is a potential target for cancer therapy. The UPP degrades unfolding or damaged proteins by an ATP-dependent mechanism (Ciechanover, Elias, Heller, Ferber, & Hershko, 1980). It also plays an important role in α-Conotoxin PIA calculato

• TP-0903 Global inhibition of integrin signaling with EDTA

  2019-08-17

  

  Global inhibition of integrin signaling with EDTA here suggests that integrin signaling potentially cooperates with DDR2 in collagen induction of lysyl oxidase. This notion is supported by a recent study that shows DDR2 cooperation with specific integrins in cell adhesion to collagen [47]. It is of

• Acidic substituents showed moderate biochemical activity but

  2019-08-17

  

  Acidic substituents () showed moderate biochemical activity, but these compounds showed reduced cellular potency. Additional compounds bearing a carboxylic GMX1778 were also prepared and tested (data not shown). All of acidic compounds showed low cellular potency regardless of their biochemical act

• br Experimental protocols br Acknowledgements

  2019-08-16

  

  Experimental protocols Acknowledgements This research was funded by the Croatian Ministry of Science, Education and Sports (Programmes 098-0982915-2948 and 098-0982522-2525), the Austrian Science Fund FWF (DK-MCD W1226, SFB LIPOTOX F30, P22832), and the Croatian-Austrian Intergovernmental S&T

• br Particle swarm optimization for NLBP br Computational tes

  2019-08-16

  

  Particle swarm optimization for NLBP Computational tests Conclusions Acknowledgements This work was supported by the State Key Development Program for Basic Research of China (No. 2009CB421104) and the National Natural Science Foundation of China (Nos. 50809004 & 41071323). Main Text

• br Physiological roles for EPAC isoforms

  2019-08-16

  

  Physiological roles for EPAC isoforms: vascular function The effects of cAMP on limiting vascular endothelial cell (VEC) inflammation and vascular smooth muscle cell (VSMC) proliferation have been well documented 36, 37, 38. However, recent work has demonstrated that several key effects of cAMP i

• br Signaling of DDR receptor and its regulation Being the

  2019-08-16

  

  Signaling of DDR2 receptor and its regulation Being the tyrosine kinase receptor, downstream signaling of DDR2 receptor is initiated by phosphorylation of cytoplasmic tyrosine residue upon ligand binding (Type II collagen) but the authentic facts or detail information of tyrosine phosphorylation

• br Experimental Procedures br Acknowledgments We thank S Tan

  2019-08-16

  

  Experimental Procedures Acknowledgments We thank S. Tangye and A. Swarbrick for helpful discussions and critical reading of the manuscript; K. Wood, T. Camidge, and V. Turner for technical assistance; C. Brownlee for cell sorting; the staff of the Garvan Institute Biological Testing Facility f

• The idea that ASB can drive compartment expansion in

  2019-08-16

  

  The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma blasticidin powder [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2) cell

• Currently two approaches can be

  2019-08-16

  

  Currently, two approaches can be used individually or combinedly to overcome weak immunogenicity of subunit YM155 (Bookstaver et al., 2018; Moyle, 2017; Vartak and Sucheck, 2016). The first is to design particulate antigens. Virus-like particles (VLPs), for example—mainly derived from the capsid pro

• Another mechanism underlying on the toxicity of

  2019-08-16

  

  Another mechanism underlying on the toxicity of dopaminergic neurons might be related to dopamine-dependent initial oxidative stress [60]. Dopamine 4 68 mediated by monoamine oxidase (MAO) can produce hydrogen peroxide as a by-product, and excess dopamine can undergo auto-oxidation to quinones or s

• br Conclusions The PQQ dependent CcPDH is

  2019-08-16

  

  Conclusions The PQQ-dependent CcPDH is the first PQQ-dependent enzyme identified in eukaryotes. The PQQ cofactor binds the enzyme with high affinity, reflected in a Kd of 1.1 nM, and the enzyme oxidizes 2KG, l-fucose, and rare sugars such as d-arabinose and l-galactose. The AA8 cytochrome b domai

• We aim to apply the same

  2019-08-16

  

  We aim to apply the same technology to target other collagen-binding proteins using motifs from collagens that are specific for other receptors or matrix components. Previously, we synthesized THP libraries, called Toolkits, composed of an active guest sequence flanked by five GPP host triplets that

14858 records 908/991 page Previous Next First page 上5页 906907908909910 下5页 Last page