See Supplemental Experimental Procedures for a more detailed

2018-10-20

See Supplemental Experimental Procedures for a more detailed description of methods used in this study. Author Contributions Acknowledgments Introduction Fanconi anemia (FA) is an autosomal recessive disorder associated with birth defects, progressive bone marrow failure, hematopoietic ste

br Results br Discussion Our first goal

2018-10-20

Results Discussion Our first goal in these studies was to establish an immunodeficient mouse model of hyperglycemia associated with insulin resistance and obesity that would resemble a type 2 diabetes phenotype. It was not feasible to transplant human progenitor cells into traditional models o

br Experimental Procedures br Author Contributions

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Multipotent human mesenchymal stromal PJ34 cost (hMSCs) are somatic progenitors that can be isolated from bone marrow (BM) (Friedenstein, 1976; Pittenger et al., 1999) and many other sites, such as adipose tissue,

The analysis of skeletal muscle regeneration and SC

2018-10-20

The analysis of skeletal muscle regeneration and SC self-renewal following transplantation indicated that huSCs expanded in the presence of p38i exhibited tissue regenerative and self-renewal potential exceeding that of even freshly isolated quiescent huSCs. Given that quiescent huSCs are no more di

br Introduction Neural tube defects NTDs are

2018-10-20

Introduction Neural tube defects (NTDs) are still poorly understood, especially for human and non-human primates (NHPs) (Wallingford et al., 2013). In rhesus monkeys, at embryonic day 19–20 (E19–20), the neural tube (NT) contains multiple pseudostratified layers of neuroepithelial stem cells (NES

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2018-07-29