Using murine ESCs Correa Cerro et al screened the

2018-10-20

Using murine ESCs, Correa-Cerro et al. (2011) screened the effect of single overexpressed TFs from a panel of 137 transcription factors and selected for those which had the ability to induce a transcriptome shift towards specific lineages at 48h post induction. They followed that report by testing s

The following are the supplementary data related

2018-10-20

The following are the supplementary data related to this article. Author contribution Acknowledgements A considerable part of the cost of this study was covered by funds of the National Strategic Reference Framework (NSRF) 2007–2013 (Region of Epirus) (NSRF/2007-13/2011ΕΠ01880025). The title

Cell transplantation therapy is a promising approach to prom

2018-10-20

Cell transplantation therapy is a promising approach to promote remyelination in MS patients; human embryonic stem perk kinase (hESCs) and induced pluripotent stem cells, as well as fetal brain, are potential sources of therapeutic cells (Brüstle et al., 1999; Müller et al., 2006). Studies in anima

With these results we provide evidence

2018-10-20

With these results, we provide evidence that the transplantation of iPSC-derived NSCs could have a beneficial role in modifying the course of SMARD1. Regarding the translational safety of iPSC-derived cells, one major finding of this study is that adverse events such as tumorigenesis or abnormal gro

gallic acid We next used the high content imaging to further

2018-10-20

We next used the high-content imaging to further define hypertrophic pathway interactions in hESC-CMs and hiPSC-CMs and to compare this with data defining the phosphorylation effects of PE treatment. We have developed 2D and 3D imaging processes to analyze hypertrophic phenotype of our gallic acid

br Results br Discussion Direct reprogramming of human somat

2018-10-20

Results Discussion Direct reprogramming of human somatic lorcaserin buy online into functional neurons has been proposed as an alternative strategy to obtain patient-specific neurons for disease modeling, drug screening, and toxicity tests (Qiang et al., 2014). Indeed, this approach offers so

See Supplemental Experimental Procedures for a more detailed

2018-10-20

See Supplemental Experimental Procedures for a more detailed description of methods used in this study. Author Contributions Acknowledgments Introduction Fanconi anemia (FA) is an autosomal recessive disorder associated with birth defects, progressive bone marrow failure, hematopoietic ste

br Results br Discussion Our first goal

2018-10-20

Results Discussion Our first goal in these studies was to establish an immunodeficient mouse model of hyperglycemia associated with insulin resistance and obesity that would resemble a type 2 diabetes phenotype. It was not feasible to transplant human progenitor cells into traditional models o

br Experimental Procedures br Author Contributions

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Multipotent human mesenchymal stromal PJ34 cost (hMSCs) are somatic progenitors that can be isolated from bone marrow (BM) (Friedenstein, 1976; Pittenger et al., 1999) and many other sites, such as adipose tissue,

The analysis of skeletal muscle regeneration and SC

2018-10-20

The analysis of skeletal muscle regeneration and SC self-renewal following transplantation indicated that huSCs expanded in the presence of p38i exhibited tissue regenerative and self-renewal potential exceeding that of even freshly isolated quiescent huSCs. Given that quiescent huSCs are no more di

br Introduction Neural tube defects NTDs are

2018-10-20

Introduction Neural tube defects (NTDs) are still poorly understood, especially for human and non-human primates (NHPs) (Wallingford et al., 2013). In rhesus monkeys, at embryonic day 19–20 (E19–20), the neural tube (NT) contains multiple pseudostratified layers of neuroepithelial stem cells (NES

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2018-07-29