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Interaction between AhR and ligands leads to AhR
2024-09-10
Interaction between AhR and ligands leads to AhR transformation (Fig. 1), characterized by a rapid receptor nuclear translocation and the formation of AhR/Arnt complex and the release of the chaperone proteins. Following AhR transformation, the AhR/Arnt complex binds to its cognate DNA consensus seq
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br Materials and methods br Results br Discussion
2024-09-09
Materials and methods Results Discussion The data presented here demonstrate the important role of B lymphocyte-expressed α7 nAChRs in regulating the antibody immune response. It is shown that, in addition to ACh produced by activated T lymphocytes (Fujii et al., 2012), activated B lymphocy
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At present the role of autophagy in neurons remains controve
2024-09-09
At present, the role of autophagy in neurons remains controversial. Autophagy has homeostatic and waste-recycling functions and plays a protective role in neurodegeneration diseases. Moreover, it has been thought as a programmed cell death participating in the occurrence and development of various d
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ATP citrate lyase ACLY is a
2024-09-09
ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl-CoA from citrate [15]. Acetyl-CoA is the building block for the biosynthesis of fatty acids and cholesterol, and also serves as a substrate of the acetylation reaction of various molecules, including histones and
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In the nineties we knew
2024-09-09
In the nineties we knew that (-)baclofen was the stereo-selective ligand for the GABAB receptor which had been recognised by Norman Bowery as a receptor for GABA, which was different from the GABAA receptor (Hill and Bowery, 1981). GABAB receptor antagonists were also synthesised and made available
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br Material and methods br Results
2024-09-09
Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential AG-120 receptor for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparagi
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Isochlorogenic acid C br Materials and methods br Results br
2024-09-09
Materials and methods Results Discussion The current treatment modalities for colorectal cancer are hampered by various issues such as high acquired resistance, long-term complication with potential of cancer recurrence, severe side-effects and poor therapeutic index [50], [51], [52]. Compl
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Overall the expression of both
2024-09-09
Overall, the expression of both components (ligand and receptor) of the apelin signaling system allows for analysis of the direct role of apelin in CL function, and specifically P4 production. Although the CL secretes many different hormones, P4 is of predominant importance because it is necessary f
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Introduction Heterotrimeric G proteins mediate signal transd
2024-09-09
Introduction Heterotrimeric Gαβγ proteins mediate signal transduction through seven-transmembrane domain receptors. In response to neurotransmitters or hormones, activated receptors bind GTP via the Gα subunit leading to the dissociation of Gα from the Gβγ dimer. G proteins regulate the levels of s
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br The AHR functions in
2024-09-06
The AHR functions in the immune system – a tsunami of exciting findings The research of recent years has convincingly established an important function of the AHR in linking chemical environmental cues to immune responses [21,22], and reviewed in [1,23]. As a side effect, a view of the AHR as “Th
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br Preliminary remarks Expression of the transcription
2024-09-06
Preliminary remarks Expression of the transcription factor aryl hydrocarbon receptor (AHR) and the AHR-repressor (AHRR) are both strikingly high in the AT13148 australia of barrier organs skin and gut [1,2]. It is generally assumed that this reflects their role in linking environmental factors t
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In glaucoma the primary retinal defect appears in
2024-09-06
In glaucoma, the primary retinal defect appears in the GCL, whereas the other retinal layers appear normal (Kendell et al., 1995). In the current work, chronic elevation of IOP induced RGC apoptosis, especially in the GCL, and α2 adrenergic treatment reduced RGC apoptosis. Various studies have repor
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There has been growing interest over computational methods t
2024-09-06
There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it Doxofylline has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity relationship (QSAR)
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As also found by Stolarski et
2024-09-06
As also found by Stolarski et al. [14], inclusion of N2O in the model is successful in reducing the effect of dynamics [13] in the lower stratosphere in the Northern Hemisphere (30–60°N in our case). The inclusion of N2O also decreased the error bars on the trend values, but the trend values still c
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Our co IP data show that HT A or HT
2024-09-06
Our co-IP data show that 5HT1A or 5HT2A receptors do not heterodimerize with mGluR1α receptors. Given that both 5-HT and mGlu receptors are GPCRs and produce anxiolytic effects, a degree of cooperativity via a functional cross-talk may still exist between these receptors [11]. In addition to the fun
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