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Finally we show that the optimal corporate tax rate is
2023-09-14
Finally, we show that the optimal corporate tax rate is strictly positive, balancing the increase in tax revenues against the loss in consumer surplus due to higher prices and fewer firms (products). This result is related to the well-known “excessive entry theorem” that shows, for a large class of
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The indirect effect of corporate taxation as given
2023-09-14
The indirect effect of corporate taxation, as given by the second term in Eq. (18), consists of two elements; (i) a standard SR 57227 hydrochloride effect (τ/n2), and (ii) a capital cost effect (rG(1−αt)/(1−t)). With a CRS technology, the cost effect vanishes, whereas with an IRS (a DRS) technology
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Here we investigate the ATM to ATR switch
2023-09-14
Here, we investigate the ATM to ATR switch in normal human fibroblasts (82-6 cells) after irradiation with γ-rays, or high LET 56Fe and 28Si and moderate LET 16O particles. Our data provide important evidence of LET dependence on the transition of ATM to ATR as well as end resection at the sites of
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It is noteworthy that in both
2023-09-14
It is noteworthy that in both cases there is a higher risk for prematurity [44], [61], [97], [98] and for deliveries of newborn small for GA [89], [95], [97], [98]. sFlt-1:PlGF has been showed to be inversely correlated with GA at birth, since 86% of pregnant women who gave birth at Ketoconazole of
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An in vitro assay in which endothelial cells
2023-09-14
An in vitro assay in which endothelial cells form 3D tube-like structures was used to investigate effects of dNK on vessel stability. The results indicate that dNK cells from women with high spiral artery resistance index had reduced ability to activate endothelial cells, since endothelial cells pre
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br Telmisartan Telmisartan is one of
2023-09-14
Telmisartan Telmisartan is one of the widely used antihypertensive agents, which has demonstrated favorable safety and tolerability profiles, both alone and in combination therapies. It has a number of pharmacological properties that distinguish it from other ARBs—the longest plasma half-life, hi
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br STAR Methods br Author Contributions br Acknowledgments
2023-09-13
STAR★Methods Author Contributions Acknowledgments This study is funded by National Institutes of Health (NIH) Grants NS028901 and DC004450 (to L.O.T.); N.L. Tartar Trust Fellowship (to H.-W.L.); DC014878 to T.S.B. We thank members of the Trussell lab for helpful discussions, Dr. Stephen Dav
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We found evidence of the interaction between AR and
2023-09-13
We found evidence of the interaction between AR and hemiacetals by evaluating the effect of glucose on l-idose reduction. l-idose was recently proposed as the best AR substrate able to mimic glucose [38]. This aldose is structurally very closely related to d-glucose, from which it differs only in th
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Blocking the action of CREB with
2023-09-13
Blocking the action of CREB with the C646 inhibitor together with increasing Akt activation with the SC79 agonist is particularly interesting as it significantly reduced wound closure time from 7 days (which is required for complete closure of control hTECs exposed to DMSO) to only 4 days (when hTEC
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Previous studies to investigate the functions of AHR in
2023-09-13
Previous studies to investigate the functions of AHR in Treg FRAX486 have employed a loss-of-function approach, using AHR complete-null mice, or a gain-of-function approach by ligand administration. However, these approaches may confound the interpretation of the results. For example, the broad exp
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Encouraged by this observation a systematic SAR study
2023-09-13
Encouraged by this observation, a systematic SAR study on the A ring -alkoxy was conducted as summarized in . The A ring methoxy-containing KRCA-0008 was proven an optimal substituent in terms of potency after all and its bigger size derivatives were detrimental in both biochemical and H3122 cellula
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Based on our previous work and the observation
2023-09-13
Based on our previous work [13] and the observation that SNX9 is a partner for ACK, we have investigated interactions involving the SH3 domain of SNX9, and identified for the first time synaptojanin-1 as an alternate partner. This SH3 domain can bind a single site in ACK1, but multiple sites in the
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Until now there are no report regarding the
2023-09-13
Until now, there are no report regarding the relationship of CD21 and MG. In the present study, we aimed to characterize the AchR specified SU5416 and investigated the role of CD21 in immunopathogenesis of MG. We utilized the Allophycocyanin (APC)-conjugated AchR to measure the frequencies of AchR
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br Methods br Results From a study population of
2023-09-13
Methods Results From a study population of 7069 patients, a total of 149 falls were reported during the study Moniliformin sodium salt for an incidence rate (IR) of 5.2 falls per 1000 patient-days (PD), 95% confidence interval (CI) 4.4/1000 PD–6.1/1000 PD. The incidence rate ratio (IRR) for p
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br Introduction The principal pathways of adrenal
2023-09-13
Introduction The principal pathways of adrenal and gonadal steroidogenesis have been known for over 50 years (reviewed by Miller and Auchus, 2011). Cholesterol is first converted to pregnenolone via three reactions, 20-hydroxylation, 22-hydroxylation and scission of the 20,22 carbon–carbon bond,
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