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Deoxynivalenol br ABCA and cancer drug response Overall the
2024-08-16
ABCA2 and cancer drug response Overall, the expression of ABC transporters has been linked with multidrug resistance phenotypes through the efflux of drugs via ATP-dependent transport. For example, 13 distinct transporters (ABCA2, ABCB1, ABCB4, ABCB11, ABCC1–6 ABCC10, ABCC11 and ABCG2) have been
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The srd a isoforms showed unique expression profiles in
2024-08-16
The srd5a isoforms showed unique expression profiles in early FHM development (Fig. 2). Similar to amphibian embryos, there was a high abundance of both srd5a1 and srd5a3 at 1dpf in FHMs, suggesting that mRNA for these enzymes may be maternally deposited and that these enzymes may play a key role in
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br ACL A Metabolic Checkpoint for
2024-08-15
ACL: A Metabolic Checkpoint for Sensing Excess Nutrients? During normal transitions between fasting and feeding, cells maintain energy homeostasis by integrating energy and nutrient status signals at key metabolic nodes, coordinating multiple processes. For example, the AMP-activated protein kina
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We used the lead compound C to demonstrate that small
2024-08-15
We used the lead compound C4 to demonstrate that small molecule ACL inhibitors can recapitulate ACL knockdown (KD) in modulation of cancer stemness. We have shown previously that ACL KD reduced the CSC population in multiple cancer cell lines. The E-snail cells are an established CSC model system.
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Aromatization of the pyrrole ring after anion capturing usin
2024-08-15
Aromatization of the pyrrole ring after anion capturing, using acceptor atoms with electron deficiency (B & Be), and substitution of strong electron withdrawing groups such as CN were three strategies used to design a new class of anion receptors. Comparison of the anion affinities of these anion re
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In conclusion there are only a few experimental reports eval
2024-08-15
In conclusion, there are only a few experimental reports evaluating the influence of Fmoc-Thr(tBu)-OH on allergy. With the exception of studies using macrolides, most point to their harmful effect on the severity of this disease. Future studies will be crucial to define the impact of antibiotic use
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br Experimental section br Abbreviations
2024-08-15
Experimental section Abbreviations PSA, puromycin–sensitive aminopeptidase; APN, aminopeptidase N; AML, acute myeloid Leukemia; ALL, acute lymphoblastic leukemia; AADR, amino Piperine synthesis deprivation response; PAN, puromycin aminonucleoside; DCC, dicyclohexyl carbodiimide; NHS, N–hydrox
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Our studies suggest that AdipoR and AdipoR genes
2024-08-15
Our studies suggest that AdipoR1 and AdipoR2 genes are expressed in multiple tissues in the chicken wherein both receptors are likely to mediate the physiological effects of adiponectin. We determined the relative expression of AdipoR1 and AdipoR2 mRNA in various tissues and found that skeletal musc
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In conclusion this study detected the expression of adiponec
2024-08-15
In conclusion, this study detected the expression of adiponectin and its receptors, AdipoR1 and AdipoR2, in goat ovarian follicles. In addition, adiponectin was shown to enhance the progression of goat oocyte nuclear maturation in vitro. The present findings provide evidence for paracrine/autocrine
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br Endocytosis of AdipoR Surface receptor activity may be sh
2024-08-15
Endocytosis of AdipoR1 Surface receptor activity may be shut down by endocytic uptake and subsequent lysosomal degradation of the proteins [20]. Clathrin-dependent endocytosis (CDE) has been extensively studied and internalization from the plasma membrane is mediated through clathrin-coated pits
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br Conclusions br Acknowledgments This research was funded
2024-08-14
Conclusions Acknowledgments This research was funded by the National Science Foundation Committee (NSFC) of China (Nos. 81171058 and 81471146) and Capital Development Scientific Research in China (Nos. 2011-5001-04 and 2014-4-5013). We are grateful for all of the participants who donated blood
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sphingosine Protein blast analysis of the sequence of globin
2024-08-14
Protein blast analysis of the sequence of globin-B with those of other sphingosine suggests that the globin-B domain in the HemAC-Lm displays only 6% identity and 34% similarity with that of cytoglobin/neuroglobin (Fig. 2). Furthermore, SWISS-MODEL protein modeling also predicts that the His311 is
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Given these findings above we hypothesized that hypernocicep
2024-08-14
Given these findings above, we hypothesized that hypernociception produced by intra-amygdala 8-OH-DPAT is result of hyperpolarization in this area. This neuronal inhibition of the amygdaloid complex might result in an inactivation of crucial neurotransmitter systems of the descending inhibitory pain
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The link between HPV infection and neoplasia has been
2024-08-14
The link between HPV infection and neoplasia has been well established. HPV encodes two oncogenes (E6 and E7) that drive luna dna progression by controlling the functions of tumor suppressor proteins p53 and Rb [7]. HPV is associated with more than 99% of cervical CESC cases [8]. CESC remains a maj
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Aurora A and B are
2024-08-14
Aurora A and B are required for the control of mitosis whereas Aurora C is mainly invoved in meiosis (Goldenson and Crispino, 2015). Interestingly, Aurora B is partnered with inner centromere protein (INCENP), survivin and Borealin to form a chromosomal passenger complex (CPC) that is critical for t
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