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br Conflict of interest statement
2024-08-14
Conflict of interest statement Acknowledgments Introduction Cellular responses to genotoxic stress in eukaryotic cells are coordinated by members of the phosphoinositide kinase related protein kinase (PIKK) family. Two members of this family, Ataxia–Telangiectasia mutated (ATM) and ATM and
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semagacestat sale br Interaction between ASK and TRX Thiored
2024-08-14
Interaction between ASK1 and TRX Thioredoxins are small (∼12kDa) dithiol oxidoreductases ubiquitously expressed in species ranging from plants to archaea and mammals. They perform various biological functions, such as reducing protein disulfide bonds, supplying reducing equivalents to redox semag
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Wound healing without blastema formation causes partial rest
2024-08-14
Wound healing without blastema formation causes partial restoration of lost tissue, and gives rise to fibrotic scars. Healing by fibrotic scarring rather than by regeneration leads to tissue dysfunction, and can place a huge burden for the health of the animal [4]. Therefore, understanding the molec
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br Experimental EPR spectra of probes a f were
2024-08-14
Experimental EPR spectra of probes 1a–f were recorded on a Bruker EMX-1572 operating at X-band (9.0–9.9 GHz), at 21 ± 1 °C. The EPR parameters were the same in all experiments: microwave power, 1 mW; modulation amplitude, 5 G; time constant, 10.24 ms; and conversion time, 40.96 ms. Reduced gluta
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Thalidomide is now a well
2024-08-14
Thalidomide is now a well known antiangiogenic agent. This property of thalidomide is being extensively researched upon, for its significant utility in the treatment of various malignant tumors. Studies show that thalidomide efficaciously inhibits various pro-angiogenic factors such as tumor necrosi
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MD was the recipient of the
2024-08-13
MD was the recipient of the Intergroupe Francophone de Cancérologie Thoracique (IFCT) Alain Depierre Grant in 2014. JP was the recipient of the ARISTOT (Association de Recherche, d’Information Scientifique et Thérapeutique en Oncologie Thoracique) grant in 2016. Conflicts of interest statement
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br Materials and methods br Results br Discussion In
2024-08-13
Materials and methods Results Discussion In the present study, we identified HBP1 as a novel substrate of AKT. This was demonstrated by in vitro phosphorylation assays and western blotting using phosphosite-specific antibodies. Three sites were identified by mass spectrometry and mutagenesi
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To better understand the pathophysiology of ASDs we would
2024-08-13
To better understand the pathophysiology of ASDs, we would need comprehensive information on a) the functions of ASD-associated proteins in the brain, b) how mutations affect the expression level and function of these proteins, c) how mutations affect their function in neurons, and d) how changed ne
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In this study significant reduction in the HCO content in
2024-08-13
In this study, significant reduction in the HCO3− content in sham-operated and testosterone-treated rats following bafilomycin A1 administration suggested that V-ATPase could be involved in mediating the decrease in vas deferens fluid HCO3− content, most probably due to the increase in H+ secretion
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According to the present observations the Ampk
2024-08-12
According to the present observations, the Ampkα1 isoform promotes AP-1 transcriptional activity and thereby fosters Bax inhibitor peptide V5 of AP-1 target genes in cardiomyocytes via activation of Pkcζ. The transcription factor AP-1 plays a decisive role during cardiac remodeling [24], [25], [26],
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br Conclusions and perspectives In view of the evidences sup
2024-08-12
Conclusions and perspectives In view of the evidences supporting that akt inhibitor MAS receptors mediate the effects of AT1 antagonists (Iwai et al., 2012, Ohshima et al., 2014, Pernomian et al., 2015, Schuchard et al., 2015), the prime targets from the perspectives on future directions in the i
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In this study we have generated new FRET reporters
2024-08-12
In this study, we have generated new FRET reporters to screen all submembrane domains of AT1R for interactions with CaM. We identified a new CaM-binding domain on the receptor’s SMD2 (a.a. 125 – 141), confirmed interactions at SMD4JM (a.a. 309 – 327) and characterized the full interacting domain in
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The rescue of the behavioral
2024-08-12
The rescue of the behavioral deficit was associated with a significant reduction in the levels of both soluble and insoluble Aβ peptides and their deposition in the Phosphatase Inhibitor Cocktail 3 (100X in DMSO) of the same animals. In search for the mechanism behind the reduced amyloidosis, we as
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Imaging QTL studies may have several potential
2024-08-12
Imaging QTL studies may have several potential advantages over case-control studies, including increased power . Imaging endophenotypes of disease in QTL studies can separate patients and normal subjects more accurately and therefore limit the confound of including asymptomatic subjects in the contr
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br Glioblastoma GBM is the highest grade glioma Grade IV
2024-08-12
Glioblastoma GBM is the highest-grade glioma (Grade IV) according to WHO classification and belongs to the most malignant form of colometric tumor. It is an incurable disease despite the use of aggressive treatments that include surgery and radiotherapy, usually in combination with chemotherapy
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