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br Acknowledgments br Introduction Guanosine cyclic
2022-10-04
Acknowledgments Introduction Guanosine 3′,5′-cyclic monophosphate (cGMP) is a signaling molecule with key roles in diverse (patho) physiological responses and processes in numerous prokaryotes and all eukaryotes. The number of reports stating the role of cGMP in different processes in plants i
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NPxY was recognized as the first short
2022-10-04
NPxY was recognized as the first short signal sequence motif in the cytoplasmic domain of membrane receptors and proteins with critical roles in internalization and trafficking of receptor molecules [130]. Including LDL receptor, beta-1 integrin, megalin, beta-amyloid precursor protein, EGF receptor
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We did however observe that niacin
2022-10-04
We did, however, observe that niacin treatment impaired DC accumulation in skin-draining lymph nodes (Fig. 2). Attenuated adaptive immunity, assessed using a contact hypersensitivity assay (Fig. 4), was observed, as would be expected from impaired DC accumulation in lymph nodes, though other mechani
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Adenosine triphosphatase ATP is a signaling molecule in
2022-10-04
Adenosine triphosphatase (ATP) is a signaling molecule in acute pain and chronic pain(Burnstock, 2009, Burnstock, 2013, Burnstock, 2014, Chizh and Illes, 2001). It is also known that presynaptic A1 receptors are involved in the inhibition of transmitter release (Vizi and Knoll, 1976). Extracellular
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We found that most antigenic regions in GlyT
2022-10-04
We found that most antigenic regions in GlyT1C are located in the second half of the GlyT1C-terminus, which is in concert with previously published results (Olivares et al., 1994). We however further show that in contrast to epitopes 554–625 which are affected by calcium only minimally, the epitopes
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br Conflict of interest statement br Acknowledgements
2022-10-03
Conflict of interest statement Acknowledgements This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grants [1061044], [1065410] and [1126857], and NHMRC program grant [1055134]); P.M.S. and A.C. are NHMRC Principal and Senior Principal Rese
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br Competing interests br Acknowledgements br
2022-10-03
Competing interests Acknowledgements Introduction - Factors Regulating Glucose Tolerance Strictly speaking, the incretin effect refers to the amplification of insulin secretion, which occurs when GSK J1 is taken in orally as compared to infused intravenously [1]. Normally, the insulin respo
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br Pathological consequences of disruption in the GABA T
2022-10-02
Pathological consequences of disruption in the GABA/T current equilibrium This issue has been particularly investigated in the context of absence seizures. These seizures are non-convulsive epileptic attacks present in many generalized genetic epilepsies that are characterized by a sudden and rel
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FFAs concentration response curves for
2022-10-02
FFAs concentration–response curves for increasing intracellular calcium and receptor phosphorylation showed a difference of ≈1 order of magnitude indicating a relatively large receptor reserve, which is expected for a transfected model, and that high receptor occupancy is necessary to induce recepto
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br STAR Methods br Acknowledgments We thank the Shanghai
2022-10-02
STAR★Methods Acknowledgments We thank the Shanghai Synchrotron Radiation Facility (SSRF) BL18U for help with X-ray data collection. We thank Dr. Thomas F.J. Martin for providing the pcDNA3.1-CAPS-1 plasmid and Dr. Xiaofei Yang for providing the pFHUUIG_shortU6 (l309) plasmid. We thank Dr. Shun
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cimetidine tagamet In our study SHH protein overexpression w
2022-10-02
In our study, SHH protein overexpression was significantly associated with lymph node metastasis which is in agreement with the study done by Marechal et al. wherein they have reported that SHH is a prognostic biomarker in PDAC and high levels correlate with lymph node metastasis (Maréchal et al., 2
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br Acknowledgments br Introduction Myelin one of the fundame
2022-10-01
Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the CGS 35066 of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwann cells (SC) in th
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To confirm that these were
2022-09-30
To confirm that these were bona fide interactions, we investigated whether the potassium channel subunits or Tmem263 formed complexes with GLT-1 or DAT after immunoprecipitation. Lysates of HEK-293 cells previously cotransfected with HA-GLT-1 or HA-DAT, and either YFP-Kv7.3, YFP-Kv7.2 or YFP-Kv7.5 w
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The functionally crucial arginine within M
2022-09-30
The functionally crucial arginine within M2 is not encoded by the gluR2 gene, but rather arises within the pre-mRNA by editing of a codon for the neutral glutamine residue25, 26. RNA editing at the Q/R site is specific to GluR2 and is extremely efficient. In neonatal and adult rat brain, almost 100
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br Introduction Glucose homeostasis is
2022-09-30
Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β PEG Virus Precipitation Kit is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major coun
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