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STF-118804 Initial studies generally focused on the co
2022-08-18
Initial studies generally focused on the co-administration of glutamate with transport inhibitors and clearly revealed the ability of the blockers to exacerbate excitotoxic injury in both in vitro and in vivo models (McBean & Roberts, 1985, Robinson et al., 1993a). In addition to demonstrating the c
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LPCs have been previously described
2022-08-18
LPCs have been previously described as potential anti-diabetic factors due to stimulation of secretory activity from the isolated rodent pancreas, L-type cells, ands insulin-producing cell lines, with LPC 18:1 as the main structure of interest (Soga et al., 2005, Sakamoto et al., 2006, Overton et al
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Prior to cellular uptake studies of
2022-08-18
Prior to cellular uptake studies of (3S,5S)-Atorvastatin sodium salt , docking simulation was performed (A). The result suggested this complex was capable of binding in the cavity of an outward open XylE. The orientation of the sugar moiety in the docked complex was similar to that of the glucose u
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p53 apoptosis br Acknowledgements This work was supported
2022-08-18
Acknowledgements This work was supported by the National Institutes of Health [grant number GM024417]. Introduction In mammals, glucose is the major energy substrate supporting conceptus development after p53 apoptosis formation [1,2]. While the equine morula uses similar amounts of pyruvate
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Nowadays there is no information if bifunctionality is an
2022-08-18
Nowadays, there is no information if bifunctionality is an exclusive trait of the order Methanococcales or if this characteristic is shared by other orders from archaea, like Methanosarcinales. These organisms are mainly methanogenic, and are not able to use exogenous hexoses as carbon source for ce
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Acknowledgments br Introduction The gut derived
2022-08-18
Acknowledgments Introduction The gut-derived hormone oxyntomodulin (OXM) is a naturally occurring dual agonist of both the glucagon receptor (GCGr) and glucagons-like peptide 1 receptor (GLP-1r). Structurally OXM is the 29 triapine of glucagon with a C-terminal octapeptide tail. Administration
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br Materials and methods br Results br Discussion
2022-08-18
Materials and methods Results Discussion Ghrelin is reported to regulate a number of processes related to cancer progression including tumor cell proliferation, apoptosis and metastasis [3,7,[15], [16], [17], [18], [19], [20], [21], [22]]. In the present study, we examined the potential eff
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A group of small molecule with
2022-08-18
A group of small molecule with a more promising therapeutic mechanism are known as γ-secretase modulators (GSMs), which modulate the cleavage activity of γ-secretase (and likely a host of other substrates) and specifically reduce the levels of the fibrillogenic Aβ42 peptide without altering the ε-si
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br The interrelationship between obesity
2022-08-18
The interrelationship between obesity and galanin Numerous studies revealed that obesity and galanin may promote each other. On the one hand, galanin may increase the possibility of obesity of subjects via boosting their appetite and food intake. Acute injection with galanin or its agonist, galan
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Introduction galactosidase d galactoside galactohydrolase or
2022-08-18
Introduction β-galactosidase (β-d-galactoside galactohydrolase or lactase; EC 3.2.1.23) is an important type of glycoside hydrolase that can catalyze the conversion of lactose to dextromethorphan hydrobromide australia and galactose. Furthermore, it can also catalyze transglycosylation reactions,
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br Materials and methods br Results and discussion br
2022-08-18
Materials and methods Results and discussion Conclusions Notes Declaration of interest statement Acknowledgment This work was supported by the National Natural Science Foundation of China (No. 21775132, 21505112), Scientific Research Foundation of Hunan Provincial Education Departm
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br Role of FPRs in Cancer br Concluding
2022-08-18
Role of FPRs in Cancer Concluding Remarks Activation of FPRs by formylated bacterial peptides or by host-derived mitochondrial peptides is required for local control of infection and wound healing. Nevertheless, various detrimental effects can result from the release of formylated peptides int
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br Introduction The term autophagy
2022-08-18
Introduction The term “autophagy” was coined by Christian de Duve in 1963 to describe the process of removing and degrading intracellular components such as unused proteins and damaged organelles through lysosomes [1,2]. Autophagy has been divided into three main types, namely, macroautophagy, mi
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The feasibility of using the Fas Fas ligand FasL system
2022-08-18
The feasibility of using the Fas/Fas ligand (FasL) system to target vascular progenitor Methimazole australia contributing to intimal hyperplasia has been shown in many studies [[18], [19], [20], [21], [22], [23], [24]]. Fas receptor, a member of tissue necrosis factor family, is a death receptor t
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The suboptimal trypsin selectivity profile
2022-08-18
The suboptimal trypsin selectivity profile of DPC423 prompted us to investigate additional P moieties for potency and selectivity. Glycinamide P () showed low nanomolar binding affinity against fXa which suggested that this P moiety sits deeper into the S pocket of fXa. To further elaborate on this
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