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Polyunsaturated fatty acids PUFAs represent a class
2022-08-13
Polyunsaturated fatty acids (PUFAs) represent a class of lipids that contain two or more carbon double (unsaturated) bonds (CC) and classified as n-3, n-6 and n-9 fatty acids. PUFAs including n-3 such as docosahexaenoic hexamethonium mg (DHA), eicosapentaenoic acid (EPA) and n-6 such as arachidonic
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br Conclusion br Introduction Gastric adenocarcinoma GA is t
2022-08-13
Conclusion Introduction Gastric adenocarcinoma (GA) is the fifth most commonly diagnosed malignancy and the third most common cause of death due to cancer worldwide. It is a highly aggressive cancer and 5-year survival rate (5YSR) is usually fatty G-36 synthesis might be one of the critical b
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br Acknowledgements This work was supported by NIH HL
2022-08-13
Acknowledgements This work was supported by NIH HL111674 (JHF), and the Antoinette E. (“Mimi”) & Herman Boehm Foundation (JK). The authors wish to acknowledge the valuable assistance of the Functional Genomics Core of the University of Colorado, Denver. Introduction The 21-gene recurrence sco
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Further SAR was explored with the imidazole series
2022-08-12
Further SAR was explored with the imidazole series to achieve better enzyme inhibition activity (). In comparison to published earlier, replacing the amide with sulfonamide and reverse sulfonamide maintained the GSNOR inhibitory activity. It is clear that exchanging the phenyl ring (, and ) by t
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PYR-41 Furthermore the role of GSK in the pathogenesis of in
2022-08-12
Furthermore, the role of GSK-3 in the pathogenesis of inflammation has been widely documented as it accompanies inflammatory conditions such as diabetes mellitus, mood disorders, Alzheimer’s disease, cancer (Jope et al., 2007), and has been associated with atherothrombotic CVD events. However, anoth
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In this review we aim to provide a comprehensive
2022-08-12
In this review, we aim to provide a comprehensive understanding of: 1) how AT-resident CD4+ T cell subpopulations regulate the metabolic status of AT; and 2) how adipocytes as antigen presenting cells to modulate the activities of CD4+ T cell subpopulations in AT. Under condition with obesity, ad
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The calculations for the R substrate showed that
2022-08-12
The calculations for the R substrate showed that, like the S substrate, the coordination shell of the Zn 324 4 is more symmetric than in the HIC-SG crystal structure. This symmetry indicates that the enzyme could use the same reaction mechanisms as for the S substrate, but with exchanged roles of G
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As discussed above both endogenous and exogenous lesions
2022-08-12
As discussed above, both endogenous and exogenous lesions can lead to adverse health effects [43]. Damaged nucleobases can block DNA replication which is often lethal to cells [44]. The effectiveness of DNA restoration by DNA glycosylases should be closely monitored to gain an insight of the functio
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br Acknowledgements This work is supported by
2022-08-12
Acknowledgements This work is supported by the Cognitive Sciences and Technologies Council of Iran (CSTC, Grant No. 95P31), the Iran National Science Foundation (INSF) and the Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. The authors wish to thank Dr. Ayat Kaeidi for his
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FFAR is highly expressed not only
2022-08-12
FFAR1 is highly expressed not only in β cells but also in α tyrosine kinase receptor (Segerstolpe et al., 2016), which gives the interesting perspective that 20-HETE may function both as an autocrine and as a paracrine regulator of islet cell function (Figure 1A), i.e., acting in symphony with the m
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br The GLI code The
2022-08-12
The GLI code The GLI code model [21], [22] considers the total GLI function as a balance of positive activator (GLIA) and negative repressive (GLIR) activities with GLI1 being mostly a positive transcription factor and GLI3 mostly a transcriptional repressor. The GLIA:GLIR ratio is thus critical,
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Piezo channels can be activated
2022-08-12
Piezo channels can be activated by many mechanical stimuli . While some of these stimulations directly mimic physiological forces experienced by GSK503 , such as shear stress applied in a microfluidic chamber, the most commonly used modes of stimulation consist of stretching the membrane by applying
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To ensure the induction of CYP enzymes
2022-08-12
To ensure the induction of CYP enzymes by several inducers, specific monooxygenase activities of variously induced, uninduced and pooled liver microsomes were compared (Fig. 3). Although 3-MC, phenobarbital, acetone, and dexamethasone could induce CYP1A-, CYP2B-, CYP2E1-, and CYP3A-selective enzyme
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The Hippo pathway has been well established as a
2022-08-11
The Hippo pathway has been well established as a tumor suppressor pathway and is involved in many diverse biologic processes including cell growth, cell death, and organ size control in organisms, ranging from Drosophila to mammals [4]. Central to this pathway is a kinase cascade in which the Ste20-
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Importantly both genetic deletion and pharmacological inhibi
2022-08-11
Importantly, both genetic deletion and pharmacological inhibition of FAAH also reduced NTG-induced neuronal hyperactivity in the trigeminal nucleus, which receives sensory input from craniofacial deep tissues. NTG is known to evoke the robust neuronal activation, as evidenced by the induction of the
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