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Finally life expectancy was strongly reduced in STK deficien
2022-01-03
Finally, life expectancy was strongly reduced in STK4-deficient patients. Even in those patients who received haematopoietic stem cell transplantation, the majority of patients died due to transplantation-related complications, raising the question whether MST1 expressed in nonhaematopoietic tissue
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br Experimental section The parts of chemicals and
2022-01-03
Experimental section The parts of chemicals and regents, preparation of solutions, pre-treatment of the bare Au electrode, cell culture, cytotoxicity in vitro, cell imaging, characterizations, and electrochemical measurements are supplied in the S1 (See the Supplementary Information). The prepara
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In this study we also investigated the role of GST
2022-01-03
In this study, we also investigated the role of GST Sumatriptan in relation to ASD. In univariable analyses, where the role of each GST gene (i.e., GSTM1, GSTT1, GSTP1) was individually assessed, we did not observe any significant associations between the GST genotypes and ASD. In contrast, a previo
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The ER is responsible for calcium storage lipid and protein
2022-01-03
The ER is responsible for calcium storage, lipid and protein biosynthesis, and the folding, assembly, and maturation of proteins [23], and ER stress is one of the main causes in T2DM, which leads to β-cell apoptosis and dysfunction [[5], [6], [7]]. In this study, TG was used as an ER stress inducer.
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GPR A a G protein coupled receptor
2022-01-03
GPR109A, a G-protein-coupled receptor located mainly on adipocyte cell membranes, has been identified as the molecular target for nicotinic Cyanine 5-dUTP australia [[5], [6], [7]] and mediator of NEFA reduction [5]. As a mechanism of NEFA-lowering, it is recognized that activation of GPR109A leads
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To synthesize the azaindole based compound Suzuki coupling o
2022-01-03
To synthesize the 7-azaindole based compound , Suzuki coupling of 6-chloro-7-azaindole with 4-CFO-phenylboronic Spiperone hydrochloride was carried out in the presence of Pd(dppf)Cl·CHCl to supply biaryl in quantitative yield (). Iodination at the C-3 position resulted 3-iodo-7-azaindazole . Alky
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br Materials and methods br
2022-01-03
Materials and methods Results Discussion Our data show that the ghrelin receptor, Ghsr, links energy homeostasis with a form of adult hippocampal plasticity. The presence of Ghsr on mature DG neurons suggest that acyl-ghrelin may modulate NSPCs indirectly, possibly via soluble factors such
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br Calcium permeability pathway It has been demonstrated tha
2022-01-03
Calcium permeability pathway It has been demonstrated that physiological shear stress in the circulation causes a reversible increase in Ca2+ permeability [29], [30], [31], [32], [33] and electrophysiological evidence has been recently reported for transient activation of the Ca2+-sensitive K+ ch
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Magtanong et al observed that caspase dependent apoptotic li
2022-01-03
Magtanong et al. (2019) observed that caspase-dependent apoptotic lipotoxicity of saturated fatty acids is suppressed by exogenous MUFAs. This may explain the ability of MUFAs to prevent atherosclerosis, in contrast to the pathogenicity of saturated fatty acids. Moreover, MUFAs may promote while PUF
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The F P concentration reported for a resting rabbit muscle
2022-01-03
The F6-P concentration reported for a resting rabbit muscle [20] reduced the KAapp for aldolase–FBPase complex more than 50 times compared to KAapp for aldolase–FBPase in the absence of effectors (Fig. 1b and Table 1). A standard assay for determination of FBPase activity in a complex with aldolase
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Interest in the non coding genome has
2022-01-03
Interest in the non-coding genome has recently surfaced with accelerated emphasis in the past few years (Li et al., 2016). Transcription factors (TFs) bind to enhancers and mediate RNA initiation from distal transcriptional start sites (TSS) of genes. Epigenome sequencing of human and mouse during d
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The Hardy Weinberg equilibrium was verified in all groups us
2021-12-31
The Hardy-Weinberg equilibrium was verified in all groups using the chi-square test. Using WINPEPI 11.65, the number of carriers and non-carriers of the Δ32 allele was compared between the groups through the Pearson's chi-square test with Yates's correction. Two-tailed Fisher's test was used when ap
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br GSNOR regulates SA synthesis and SA
2021-12-31
GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic Ac-DEVD-pNA (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistanc
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The timing and growth of follicles relative
2021-12-31
The timing and growth of follicles relative to follicle deviation was assessed in 49 cows (Fig. 4) that had NFWE following treatment onset and that had not already established dominance. Because day of deviation did not differ due to treatment, day of estrous cycle, or replicate, data are presented
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It is essential to maintain genome integrity
2021-12-31
It is essential to maintain genome integrity and stability which is assaulted by oxidative stress. To perform this function, all human cells have well developed repair systems. Base excision repair (BER) system is the most effective pathway responsible to revert back lesions caused by oxidative stre
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