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Chlortetracycline HCl Studies with GSNOR knockout mice repor
2021-11-09
Studies with GSNOR knockout mice reported decreased CD4+ Chlortetracycline HCl and increased CD19+ cells (B-cell) in the blood [31] as well as demyelination, neurodegeneration, and neuropathic pain [29]. To understand the basis of these differences in immune function of GSNOR knockout mice and GSNO
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For a long time the mechanism for the TG lowering
2021-11-09
For a long time, the mechanism for the TG-lowering effect of nicotinic CGP 55845 hydrochloride has been thought that the lowered NEFA substrate from adipose tissue limits TG production from the liver (so-called NEFA hypothesis) [[1], [2], [3], [4]]. However, recent emerging evidences have suggested
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In the present study participants reported a significant dec
2021-11-09
In the present study, participants reported a significant decrease in symptoms of anxiety and depression along with other symptoms of psychological distress and PTSD. These results are in agreement with a study in which hospitalized patients diagnosed with psychotic and mood disorders demonstrated s
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br Declaration of interest br Acknowledgments br
2021-11-09
Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A
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Introduction Erythrocyte membrane proteins or their ortholog
2021-11-09
Introduction Erythrocyte membrane proteins or their orthologs are found in almost all 76 2 synthesis of the body [1,2]. Because of this compositional similarity and the erythrocyte membrane's accessibility, the red blood cell membrane (RBCM) has served as a crude model for mammalian plasma membran
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br Acknowledgments This work was supported
2021-11-09
Acknowledgments This work was supported by a grant CIHR-NSFC China-Canada Joint Health Research from the National Science Foundation of China (Grant Number 81061120525) and the Canadian Institutes for Health Research (Grant number CCI-109605). The authors thank two anonymous reviewers for helpful
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Since the late s synthetic GC e g prednisone
2021-11-09
Since the late 1940s, synthetic GC (e.g. prednisone, prednisolone, dexamethasone) have been used extensively in the treatment of chronic inflammatory conditions such as rheumatoid arthritis and asthma, and for their immunosuppressant action in preventing organ rejection post transplantation. Cortico
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LXRs are physiological regulators of
2021-11-09
LXRs are physiological regulators of cholesterol and lipid metabolism and influence glucose metabolism. In addition, they have been shown to repress transcription of certain pro-inflammatory genes (Jakobsson et al., 2012; Ogawa et al., 2005; Terasaka et al., 2005). Thus, LXRs can either activate or
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Analysis of published albumin X ray structures had suggested
2021-11-09
Analysis of published albumin X-ray structures had suggested that an allosteric link may exist, but could not establish whether Zn2+ prevented FFA binding or vice versa. This question was answered through competition experiments monitored by isothermal titration calorimetry (ITC; Fig. 3) for BSA [55
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FPR ligands comprise structurally very diverse
2021-11-09
FPR ligands comprise structurally very diverse ro bio 2 of compounds, ranging from naturally occurring peptides/proteins or “danger signals” such as PAMPs and DAMPs (see 1.1), respectively, to endogenous lipids and even various synthetic non-peptides, such as benzimidazoles, pyrazolones, pyridazine
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A common feature of ferroptosis is the iron dependent
2021-11-09
A common feature of ferroptosis is the iron-dependent accumulation of lipid-ROS and the subsequent depletion of polyunsaturated fatty NSC 87877 phospholipids (PUFA-PLs) [118]. The PUFA chains of membrane lipids are more susceptible to both enzymatic and non-enzymatic oxidation, which results in PUFA
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Focal adhesion kinase FAK is a non receptor
2021-11-09
Focal adhesion kinase (FAK) is a non-receptor type tyrosine kinase that can further cooperatively interact with receptor tyrosine kinase signaling to regulate adhesion, migration, survival, proliferation, polarization, and differentiation [12]. Following activation, phosphorylated extracellular regu
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Introduction Post translational modifications to the N termi
2021-11-09
Introduction Post-translational modifications to the N-terminal tails of the histone proteins play crucial roles in genome regulation [1]. These modifications (e.g. acetylation, methylation, phosphorylation) are deposited by so-called ‘writer’ enzymes and dynamically removed by the action of ‘erase
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br Acknowledgments We thank Drs Yasuhiro Saito and Mitsuru F
2021-11-09
Acknowledgments We thank Drs. Yasuhiro Saito and Mitsuru Futakuchi for helpful discussion. We also thank Drs. Kohei Miyazono and Tadashi Matsuda for cells. This work was supported by Grant-in-Aids for Scientific Research on Innovative Area (16H06373; 16K15273) from MEXT, Japan (to M.H.) and by Pr
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GSTP has an antiapoptotic activity that is mediated by the
2021-11-08
GSTP1 has an antiapoptotic activity that is mediated by the inhibitory interaction with JNK1. Our data suggest that GSTP1 treatment is associated with a significant down-regulation of caspase expression. This might explain the reduction in infarct-related cardiomyocyte death and saving the cardiomyo
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