• br Experimental Procedures br Acknowledgments This work

  2022-01-11

  

  Experimental Procedures Acknowledgments This work was supported by NIH/National Human Genome Research Institute (NHGRI) R00 HG006922 and NIH/NHGRI R01 HG008974 (to J.G.), the Huntsman Cancer Institute, and the Women’s Cancers Disease-Oriented Team at the Huntsman Cancer Institute. Research rep

• Thirteen multiparous German Holstein cows in their second to

  2022-01-11

  

  Thirteen multiparous German Holstein cows, in their second to fourth lactation, were selected from a previous study (Schäff et al., 2012) based on their individual peak in plasma BHB concentrations in wk 2 or 3 postpartum: high BHB (H-BHB; 1.05 to 2.57 mmol/L, mean 1.59 mmol/L; n = 8) and low BHB (L

• The importance of the histone chaperone function of Hat p

  2022-01-11

  

  The importance of the histone chaperone function of Hat1p was highlighted by the recent demonstration that the catalytic activity of Hat1p is not sufficient for its function in vivo. Fusion of a nuclear export signal (NES) to yeast Hat1p effectively excluded the enzyme from the nucleus, with a conco

• Platycodon grandiflorum is a member of the

  2022-01-11

  

  Platycodon grandiflorum is a member of the genus Platycodon and is commonly known as balloon flower. In East Asia, P. grandiflorum is used for the treatment of asthma, coughs, inflammatory diseases, pulmonary tuberculosis, and diabetes (Takagi and Lee, 1972). Furthermore, recent studies have reporte

• GSTP has an antiapoptotic activity that is

  2022-01-11

  

  GSTP1 has an antiapoptotic activity that is mediated by the inhibitory interaction with JNK1. Our data suggest that GSTP1 treatment is associated with a significant down-regulation of caspase expression. This might explain the reduction in infarct-related cardiomyocyte death and saving the cardiomyo

• br Materials and methods br

  2022-01-11

  

  Materials and methods Results Discussion Although there is general agreement that GPR109A has anti-lipolytic activity and that the NEFA reduction in response to nicotinic teniposide is mediated by GPR109A, whether GPR109A activation has any impact on plasma TG levels is unclear. Since the p

• br Introduction The amino acid glycine functions

  2022-01-10

  

  Introduction The amino Icilin synthesis glycine functions as a neurotransmitter in the vertebrate central nervous system: as an inhibitory neurotransmitter and as a co-agonist of the NMDA-subtype of excitatory glutamatergic receptors (Eulenburg et al., 2005). Under a current hypothesis that schi

• br Material and methods br Results br Discussion Neurosteroi

  2022-01-10

  

  Material and methods Results Discussion Neurosteroids capable of blocking the NMDAR channel attract a lot of attention as possible therapeutic agents for the treatment of neurodegenerative diseases. A large number of new verapamil hydrochloride with different structures have been synthesiz

• br Introduction Maintaining blood glucose within an appropri

  2022-01-10

  

  Introduction Maintaining blood glucose within an appropriate range is crucial for survival. In diabetes, those who suffer episodes of severe hypoglycemia have an increased risk of death [1], [2]. The NMS-873 is especially dependent on an adequate, continuous supply of circulating glucose to fuel

• MRcKO mice showed a comparable degree of

  2022-01-10

  

  MRcKO mice showed a comparable degree of cardiac remodeling compared to control (MRf/f) mice. Moreover, the worse cardiac remodeling in pressure-overloaded GRcKO mice is not due to compensatory activation of cardiomyocyte MR, because GRMRdcKO mice displayed cardiac remodeling to the same extent as G

• Introduction G quadruplexes are therapeutically important no

  2022-01-10

  

  Introduction G-quadruplexes are therapeutically important non-canonical nucleic T-5224 structures that are formed by a planar assembly of four guanines, termed G-tetrads (Fig. 1), in the guanine rich regions of genome [[1], [2], [3]]. As it is getting increasingly established, several life forms i

• In terms of outcome measures statistically

  2022-01-10

  

  In terms of outcome measures, statistically significant differences were only observed in need for invasive mechanical ventilation (23% vs 46%, p-value 0.005) and in-hospital mortality (13% vs 37%, p-value 0.002). Both these outcomes were still statistically significant following adjustment for conf

• There are many histone H K demethylases including JMJD A

  2022-01-10

  

  There are many histone H3K9 demethylases, including JMJD1 A, JMJD2 A, JMJD2B, and JMJD2C (Kooistra and Helin, 2012). Considering that EPO Saracatinib is regulated by hypoxia, we further analyzed several hypoxia-induced H3K9 demethylases, such as JMJD1 A, JMJD2B and JMJD2C (Beyer et al., 2018; Polla

• The current study identified the presence and location of

  2022-01-10

  

  The current study identified the presence and location of all four histamine receptors in the GI tract of 6 healthy adult dogs. Although no clinical signs of GI disease were noted, mild inflammation was noted in at least one section of the GI tract in all dogs based on WSAVA guidelines. Interpretati

• SCH is a H R receptor antagonist introduced

  2022-01-10

  

  SCH-497079 is a H3R receptor antagonist introduced by Schering-Plough, without any publicized pharmacological and structural information. A Phase II clinical trial assessment of SCH-497079 on weight has been completed in a multicenter, randomized, parallel-group and placebo-controlled study in obese

15547 records 496/1037 page Previous Next First page 上5页 496497498499500 下5页 Last page