• Another interesting approach is to use partial agonists as

  2021-12-24

  

  Another interesting approach is to use partial agonists as starting point to develop specific antagonists like done in earlier decades [64], [65]. Possible indications for an attenuation of the NO/sGC signalling pathway might be specific neuronal disorders: an involvement in the aetiology of migrain

• Importantly other aspects of platelet function aggregation

  2021-12-24

  

  Importantly, other aspects of platelet function (aggregation, spreading, in vitro and in vivo thrombosis) important for haemostasis and thrombosis were unaltered in Ral DKO platelets and mice. Beyond haemostasis and thrombosis however, platelets have been implicated in numerous pathophysiological pr

• Recently it was found that hypoxia results in

  2021-12-24

  

  Recently, it was found that hypoxia results in the phosphorylation of β-catenin at Y654 in a Src-dependent manner (Xi et al., 2013). All β-catenin phosphorylated at this residue was found complexed with Hif1α and it was demonstrated that this β-catenin phosphorylation was required for Src to promote

• In plants NO production is one of the early responses

  2021-12-24

  

  In plants, NO production is one of the early responses to stress (Tossi, Lamattina, & Cassia, 2009). Usually, NO signal transduction requires the involvement of downstream signaling compounds. We further investigated the effects of cGMP on GSK-3 expression. The data showed that LY83583 (a cGMP inhib

• br Materials and methods br Results br Discussion Although t

  2021-12-24

  

  Materials and methods Results Discussion Although there is general agreement that GPR109A has anti-lipolytic activity and that the NEFA reduction in response to nicotinic L-365,260 is mediated by GPR109A, whether GPR109A activation has any impact on plasma TG levels is unclear. Since the ph

• Apart from the different assays used biased agonism could

  2021-12-24

  

  Apart from the different assays used, biased agonism could also explain the inconsistent pharmacology of GPR55. Indeed, one study compared the effect of LPIs and Virodhamine in HEK293 pikfyve inhibitor stably transfected with human GPR55. They found that the effect of both ligands on intracellular C

• There are three classes of receptors for herpes

  2021-12-24

  

  There are three classes of receptors for herpes virus gD have been described [18,24]. Among those three, herpes virus entry mediator A (HveA) is also known as HVEM. This receptor is a member of the tumor necrosis factor receptor (TNFR) superfamily [25]. The other class of receptors is HveC which is

• br Perspectives br Contributors BP study concept

  2021-12-24

  

  Perspectives Contributors BP: study concept & design, literature review, data analysis & synthesis & presentation, primary draft of the manuscript; JDR: data analysis, Fig. 1 illustration, manuscript review & revision; ZP: study concept & design, manuscript review & edit; MI: manuscript review

• The precise mechanisms of action

  2021-12-24

  

  The precise mechanisms of action of 4-PBA are as yet ambiguous. Its capacity as a chemical chaperone has been thoroughly documented for the ABC transporter family in particular (Prulière-Escabasse et al., 2007; Iram and Cole, 2014; Gordo-Gilart et al., 2016; Pomozi et al., 2017). 4-PBA has been clas

• ICH induced striatal lesion produced a reduction of EAAT exp

  2021-12-24

  

  ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino crf1 transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia (Rao e

• Tight junctions regulate the transfer of ions as well

  2021-12-24

  

  Tight junctions regulate the transfer of ions as well as small molecules across endothelial barriers (Li et al., 2015). We also investigated whether resistin affects tight junctions, which play an important role in the conformation of polarized endothelial barriers (Matsuzaki et al., 2010). A previo

• Animal studies have shown that various antidepressant treatm

  2021-12-24

  

  Animal studies have shown that various antidepressant treatment are capable of upregulating GR protein and mRNA in key CHIR-124 regions including the hippocampus and decreasing basal and/or stress-induced glucocorticoid secretion [37]. Changes in the level or function of GR regulate the negative fe

• The ER EK polymorphism is located in the

  2021-12-24

  

  The ER22/23EK polymorphism is located in the transactivation domain of the GR gene. A single nucleotide polymorphisms (SNPs) has been identified in both of the two adjacent codons (22 and 23). These SNPs are fully linked and are associated with relative GC resistance[32], [44]. Although no associati

• br GJs in the brain br Alterations of

  2021-12-24

  

  GJs in the brain Alterations of GJs in epilepsy The role of GJ blockers and openers in epilepsy As previously known, GJ-mediated electrical coupling plays a role in the generation of highly synchronous electrical activity. The hypersynchronous neuronal activity is a significant feature of c

• In a mouse model of hyperhomocysteinemia a risk factor for

  2021-12-24

  

  In a mouse model of hyperhomocysteinemia (a risk factor for the development of vascular dysfunction) it has been shown that myoendothelial communication is enhanced due to increased expression of Cx37 and IK1 CP-868596 [], allowing the propagation of endothelial signals to VSMC and thereby decreasi

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