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The redox sensitive transcription factor NF
2021-03-12
The redox sensitive transcription factor NF-κB is reported to play a crucial role in the COPD pathogenesis via up regulating the expression of several cytokines, chemokines, growth factors, and adhesion molecules [71]. Incidentally, we and others have shown that PARP-1 modulates the NF-κB activation
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br Acknowledgments The authors acknowledge
2021-03-12
Acknowledgments The authors acknowledge funding from the National Key Research and Development Program of China (2016YFA0502900) and the National Science Foundation of China (31570188). Compartment Size Regulation Regulation of compartment size is one of the most fundamental issues in biology
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Inflammation is critical in the pathobiology of atherosclero
2021-03-12
Inflammation is critical in the pathobiology of atherosclerosis. The inflammatory mediators impacted by FBXO3 described herein i.e. NF-κB, IL-1β, and TNF-α, and IL-8 have purported causal roles in atherosclerosis. For example, NF-κB activation is increased in mononuclear cells in human plaques [29]
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The BMP family comprises significant growth factors for the
2021-03-12
The BMP family comprises significant growth factors for the regeneration of bone and cartilage. Among these, BMP- has been known as an early marker during the proliferation of osteoblast cells, and one of the most potent stimulators of osteoblastic cells differentiation [40]. Studies with COX-2 knoc
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SIRT has deacetylated regulation on numerous nonhistone prot
2021-03-12
SIRT1 has deacetylated regulation on numerous nonhistone protein substrates [Atgs, Foxo1, Foxo3, PGC-1α, NF-kB, E2F1 and p53] (Conrad et al., 2016) to play a key role in protecting against cell stress. Therefore, the role of SIRT1 in fluorine-induced oxidative stress was explored. The results reveal
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The modification of proteins with
2021-03-12
The modification of proteins with the small 76-amino homoharringtonine protein ubiquitin (Ub) plays a central role in many key cellular processes. Ubiquitylation of a target protein requires the concerted action of a cascade of three enzymes (Figure 1). The ubiquitin-activating enzyme (E1) catalyze
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To further determine the cell death the
2021-03-11
To further determine the cell death, the IC261 in flasks were harvested after OGD or LTD4 treatment, washed twice with PBS, and evaluated with Annexin V (AV)-FITC apoptosis detection kit I (BD Biosciences Pharmingen, USA) on a flow cytometer (FACSCalibur, Becton–Dickinson, USA). Briefly, 106 cells
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In conclusion the magnitude of the association
2021-03-11
In conclusion, the magnitude of the association between prenatal exposure to MeHg and child neuropsychological development appears to be modified by polymorphisms in CYP3A7 and CYP3A5 genes in some of the populations studied. These results provide some support for the hypothesis that CYP3A genes may
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In contrast to AChE BuChE Table exhibited a
2021-03-11
In contrast to AChE, BuChE (Table 2) exhibited a measurable time-dependent inactivation only with Ciprofloxacin hydrochloride 2 among the four acetophenones in this study. Values of Ki obtained from steady-state inhibition of BuChE by all four acetophenones were, as noted in the Results, 10- to 200
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Otherwise ES cells express high level of histone lysine
2021-03-11
Otherwise, ES Fungicidin receptor express high level of histone lysine specific demethylase 1 (LSD1) expression. In this context, it is proposed that LSD1 inhibition may block the function of EWS-ETS proteins [70]. Furthermore, checkpoint kinase 1 (CHK1), a modulator of cell survival under the cond
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In sum although it is reasonable
2021-03-11
In sum, although it is reasonable to assume that the activities of an enzyme on alternative (metabolically available) substrates may often depend on neutral drift, the point is difficult to prove because various types of selective pressures can be at play, and these will be different in different or
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In the present study we investigated the deeper role
2021-03-11
In the present study, we investigated the deeper role of eNOS in the pathogenesis of nasal polyps and analyzed the influence of 1,8-cineol on nasal polyp gene and protein expression of eNOS in vitro. Different studies dealt with the localization and expression of eNOS in nasal polyps and nasal mucos
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Several studies on the collagen receptor DDR have
2021-03-11
Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR hmg-coa reductase inhibitor on collagens are distinct from integrin binding sites; therefore, the same collagen protein can b
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It has only recently been appreciated that antigen activated
2021-03-11
It has only recently been appreciated that antigen-activated acetylcholine inhibitor undertake two additional transient migrations during the early stages of T-dependent antibody responses. In the first of these, antigen-activated B cells migrate rapidly (within 2–3h) to the outer regions of the fo
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Recent studies have also uncovered additional roles for E
2021-03-11
Recent studies have also uncovered additional roles for E2 enzymes and E2~Ub conjugates in modulating the activity of deubiquitinating enzymes (DUBs), such as OTUB1 (Juang et al., 2012, Wiener et al., 2013, Wiener et al., 2012). Interestingly, OTUB1 has also been shown to associate and modulate the
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