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br Materials and methods br Results br Discussion Structural
2020-11-18
Materials and methods Results Discussion Structural analysis of dnmt3 sequences of different ploidy fish cloned in this study showed high similarities to zebrafish sequences, which also contained a unique N-terminal motif and a calponin homology (CH) domain, a conserved proline-tryptophan-t
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Analysis of Table shows that compound
2020-11-18
Analysis of Table 1 shows that compound 7b, in which the biphenyl scaffold does not bear any substituent, displays its inhibitory potency in the micromolar range (IC50 = 11 μM). If the amide bridge is moved from position 1 to 3 of the biphenyl system, product 7c is yielded, whose potency is about 4
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Previous synthetic lethal screening efforts Cox
2020-11-17
Previous synthetic lethal screening efforts (Cox et al., 2014) have mainly used RNAi as a means of identifying potential targets (Barbie et al., 2009, Kim et al., 2016, Luo et al., 2009, Scholl et al., 2009), although a few screens (Shaw et al., 2011, Steckel et al., 2012) have been performed with s
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Sennoside C Interestingly genome wide association studies ha
2020-11-17
Interestingly, genome-wide association studies have linked the chromosomal region harboring RDHE2 (SDR16C5) and seven other genes to stature and growth in cattle, humans, and pigs [30], [31], [32], [33], [34], [35], [36], [37], and beak deformity in chickens [38]. The most recent study specifically
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br Type II NAD P H Dehydrogenases in Fungi
2020-11-17
Type II NAD(P)H Dehydrogenases in Fungi Fermentative YeastSaccharomyces cerevisiaeBecause S. cerevisiae is a facultative TNF-alpha, recombinant human protein yeast capable of meeting its energy requirements with ATP generated by fermentation, only relatively few mitochondrial proteins are essenti
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Cryptosporidium is a protist causing serious
2020-11-17
Cryptosporidium is a protist causing serious diarrhea in humans and other animals (Bouzid et al. 2013). In its mitosomes, the most reduced forms of mitochondria, it is assumed that the membrane potential is generated by a simple respiratory chain consisting of transhydrogenase, type II NADH dehydrog
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Because flavonoids are widely considered to contribute to
2020-11-17
Because flavonoids are widely considered to contribute to health benefits in humans, including anti-inflammatory, antibacterial, antiviral, anticancer, antiplatelet properties, and free radical scavenging capacity (Xiao et al., 2011), efforts have frequently been made to increase their bioavailabili
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The sequence identity of CYP A with CYP A
2020-11-17
The sequence identity of CYP3A163 with CYP3A sequences from other species is maximum in reptiles ranging (75-91)%, gradually decreasing from D609 (63-71)% to mammals 62% to downwards based on evolutionary distances. The high level of homology with CYP3A77 in Alligator mississippiensis suggest that
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In this study we observed alterations in mRNA levels of
2020-11-17
In this study, we observed alterations in mRNA levels of CRF receptors in the PFCx and Hip during the development of sensitization. In particular, in the Hip both CRF receptors showed significantly increased Oligomycin A when the sensitization condition was established. Similarly, CRF2 receptor inc
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epinastine hydrochloride receptor In this context our observ
2020-11-17
In this context, our observation that the epinastine hydrochloride receptor predictor of positive QFN-CMV responses is background CMV seropositivity was not unexpected. Older age, despite well-known effects of CMV memory inflation did not appear to independently impact QFN-CMV responses in our study
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br Materials and methods br
2020-11-17
Materials and methods Results Discussion Persimmon tannin has been reported to have the bile acid binding ability in vitro (Matsumoto et al., 2011) and hypolipidaemic effects in animals (Matsumoto et al, 2008, Zou et al, 2012). Our previous study also proved that persimmon tannin promoted t
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Programmed cell death via apoptosis is associated with a
2020-11-17
Programmed cell death via apoptosis is associated with a series of morphological and biochemical characteristics, including cell shrinkage, the rapid increase of intracellular calcium, nuclear condensation, DNA fragmentation and the formation of apoptotic bodies. Known as a shared feature of most ap
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br Materials and methods br Results br
2020-11-17
Materials and methods Results Discussion The main finding of the present study is that selective ETA and dual ETA/ETB receptor blockade markedly improve endothelium-dependent vasodilatation in patients with type 2 diabetes and vascular complications. The magnitude of improvement did not dif
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Impulsive burying and freezing behaviors in response
2020-11-17
Impulsive burying and freezing behaviors in response to aversive stimuli may represent attempts to avoid novel and/or aversive stimuli. These behaviors can be assessed utilizing the marble burying and conditioned fear tasks, respectively. For example, Wistar rats in proestrus and ovariectomized rats
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River sand was graded in accordance with ASTM
2020-11-17
River sand was graded in accordance with ASTM C778 [47] (see Table 2). The graded sand had a water SQ 29,548 of 1.00%, fineness modulus of 3.49 and specific gravity of 2350kg/m3. A polycarboxylate based superplasticizer called ZP with pH of 7±1 and specific gravity of 1.1±0.02 was also used to adju
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