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Furthermore positioning the naphthalene nucleus in
2020-08-10
Furthermore, positioning the naphthalene nucleus in 3d within the main active site and forming one hydrogen bond with Tyr385 in addition to many hydrophobic interactions with Val349, Leu352, Gly526, Ala527 and Leu531 residues, correlates well with the position and hydrophobic interactions of the tri
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br Acknowledgments We thank the Lapaha Community and
2020-08-10
Acknowledgments We thank the Lapaha Community and Nobles (His Serene Highness Prince Kalaniuvalu Fotofili, Her Serene Highness Princess Marcella Taumoepeau Tupou Kalaniuvalu Fotofili and Her Royal Highness Mele Siu\'ilikutapu Kalaniuvalu Fotofili) and the Ministry of Internal Affairs (Government
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br Materials and methods br Results and discussion br Conclu
2020-08-10
Materials and methods Results and discussion Conclusions The current research work deals with preparation of CES from RHA and comparative study of Ni (II) ion adsorption on CES and RHA. It was observed that carbon embedded silica shows more porous structure and more surface area as compared
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Previously we have reported that magnitude of the
2020-08-10
Previously, we have reported that magnitude of the disruption of the blood–aqueous barrier after paracentesis was reduced by 82% in EP4 receptor knockout mice (Biswas et al., 2006). In the present study, we observed that pretreatment of EP1 receptor knockout mice with EP4 receptor antagonist, reduce
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Anaesthetized mice of one eNOS KO strain showed a paradoxica
2020-08-10
Anaesthetized mice of one eNOS-KO strain showed a paradoxical decrease in blood pressure (BP) in response to i.p. administration of the NOS-inhibitor L-NA suggesting a role for non-endothelial isoforms of NOS in maintaining BP [1]. Alternatively, diminution in the activity of the renin-angiotensin s
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The contribution of local ETA and
2020-08-10
The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor Rosiglitazone in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies
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AS1404 How does APC C recognize its substrates
2020-08-10
How does APC/C recognize its substrates and catalyze their ubiquitylation? How are the outcomes and timing of these activities regulated? These questions have driven a decade of structural studies that begin to explain how APC/C interacts with coactivators, substrates, and E2s, and how these interac
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In anticipation of an approach based on modification
2020-08-08
In anticipation of an approach based on modification of the cyclohexylacetic salubrinal mg subunit of 1 as a means of improving permeability, a set of analogs were prepared to map out the optimum display of the acidic functionality. Homologated acids 25 and 26 were found to be equipotent to 1, altho
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Several studies suggest that the beneficial metabolic effect
2020-08-08
Several studies suggest that the beneficial metabolic effects of adiponectin in humans are primarily mediated by its HMW isoform. Increases in the ratio of HMW to total adiponectin, but not the total adiponectin level, correlated well with improved Pirfenidone sensitivity during treatment with the i
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br Steroid biosynthesis br Steroid hormone metabolism in bre
2020-08-08
Steroid biosynthesis Steroid hormone metabolism in breast cancer Conclusion Steroid hormones elicit their biological actions primarily by binding to steroid receptors such as the ER, AR, PR and GR. Although classical breast cancer diagnostic panels assess the expression of the ER and PR, as
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Centralised waste management has known to fail at scale larg
2020-08-08
Centralised waste management has known to fail at scale, largely because of the complexity while decentralised systems however run on smaller, but manageable scales [11]. The centralised waste disposal arrangements shift the waste management problem from the source of waste generation to waste dispo
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Cell senescence is the biological
2020-08-08
Cell senescence is the biological response to abnormal extracellular or intracellular stress. Its tumor-suppressive function has been confirmed, since it blocks tumor cells at a certain phase of cell cycle, thereby decreasing cell proliferation [36]. It has been widely confirmed that Akt or ERK sign
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More abundant CH H and
2020-08-08
More abundant CH25H and CYP7B1 expression in the outer versus inner follicle highlights the specialization of follicular stromal Dasatinib Monohydrate in these regions. One subset of stromal cells situated immediately beneath the marginal and subcapsular sinuses is the MRC (Katakai et al., 2008). Al
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br Introduction Acute lymphoblastic leukemia ALL is the most
2020-08-07
Introduction Acute lymphoblastic leukemia (ALL) is the most common malignancy in children accounting for almost 30% of pediatric cancers and 80% of childhood leukemias. Despite long-term survival and high cure rates for the majority of children diagnosed with ALL, disease relapse and resistance t
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Recently Hopkins et al reported a longer form of
2020-08-06
Recently, Hopkins et al. reported a longer form of PTEN (PTEN-Long) that is secreted into adjacent loteprednol etabonate and antagonizes PI3K/AKT signaling (Hopkins et al., 2013). This study significantly expands the functional scope of the PTEN family from intracellular to extracellular. Although
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