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Next we evaluated neutralization of
2020-04-06
Next, we evaluated neutralization of Jc1, Jc1-N534A, Jc1-ΔHVR1 and Jc1-ΔHVR1-N534A by sera from individuals chronically infected with HCV GT1 and GT2 (Fig. 4A-C). Like the results of neutralization with monoclonal imidazoline and CD81-LEL (Fig. 3), the sera poorly neutralized Jc1. Neutralization wa
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br Materials and methods br Results br Conclusion br Conflic
2020-04-06
Materials and methods Results Conclusion Conflict of interest Acknowledgements This work was supported by the National Key Research and Development Program of China (2018YFD0400302) and General Program of National Natural Science Foundation of China (31471602). Introduction A sign
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br Materials and methods br Acknowledgments
2020-04-06
Materials and methods Acknowledgments Introduction Proton pumps convert the energy of high-energy compounds into the Birinapant of protons across biomembranes. They play two physiological roles: pH regulation and the formation of proton-motive forces in their membranes. The simplest of the
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A series of monocarboxylated chalcones e
2020-04-06
A series of monocarboxylated chalcones (e.g. compounds 7 and 8, Fig. 2A) was previously identified as good CysLT1 antagonists [20], and none of them exhibited CysLT2 antagonistic activities (Supplementary Table S1). This study was consistent with reported result that CysLT2 ESI-09 was not sensitive
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The same reservoir of genes
2020-04-06
The same reservoir of SB 265610 is involved in fusions in all types of cancers, which predominantly encode kinases and transcriptional factors [102]. This makes fusion genes potential pan-cancer targets, and renders tumor categorization based on genetic profiling therapeutically reasonable. For inst
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Another interesting finding regarding substrate selectivity
2020-04-06
Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty Paprotrain at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may constitute
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Previous studies have indicated that hSSB may be phosphoryla
2020-04-06
Previous studies have indicated that hSSB1 may be phosphorylated at threonine residue 117 (T117) [13] and acetylated at lysine residue 94 (K94) [15], both of which promote hSSB1 function in response to ionising radiation exposure. Mass spectrometry screens of proteins immunoprecipitated with phospho
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HvPap a member of the cathepsin F
2020-04-03
HvPap-1, a member of the cathepsin F-like family, was identified in germinating barley seeds (Sreenivasulu et al., 2008). This enzyme participates in the mobilization of stored proteins (mainly hordeins) during the last phase of grain germination, and its activity is modulated by a propeptide or/and
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br Materials and Methods br Results br Discussion
2020-04-03
Materials and Methods Results Discussion Even though T cell checkpoint inhibitors alone have achieved impressive clinical benefit in some cancers, their application as single agents has had limited efficacy (Hamid et al., 2013; Wolchok et al., 2013). The resistance to immunotherapy is in pa
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br Model parameterization br Results
2020-04-03
Model parameterization Results and discussion Conclusion Following an approach previously proposed for SAFT-VR model, we have used PR-CPA EoS without explicitly accounting for the reactions for the modeling of CO2 and H2S-water-alkanolamine solutions. The reactions between acid gases and wa
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Hydrocortisone br Overall system architecture In this sectio
2020-04-03
Overall system architecture In this Hydrocortisone section we provide a description of the system under study, and its surrounding environment, on an “as is” basis. The architecture presented in the following is the one currently adopted on-field by ASTS (e.g., at Rome train station). The Train
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br Method br Results br Discussion In
2020-04-03
Method Results Discussion In this cross-sectional study, we investigated the relationship between the COMT ValMet polymorphism and age on regional cortical thickness in healthy adults across the lifespan. The mesocortical pathway was of primary interest because of its projections from the v
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doxercalciferol Compound was generated using a literature pr
2020-04-03
Compound was generated using a literature procedure and required two-step Dess–Martin-periodinane/Pinnick oxidation prior to the methylation of the sulfonamide. Compound () was obtained from the Suzuki coupling of the methyl ester intermediate (en route to doxercalciferol ). Hydrolysis of all methyl
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In this study the ASTM C and
2020-04-03
In this study, the ASTM C1260 and ASTM C1567 test methods were followed to conduct the ASR tests. Three mortar bars were prepared using three types of RHA (600-RHA, 150-RHA, and 44-RHA) and CFA. To prepare the mortar bars, the OPC was replaced by each type of RHA for 10% and 20%, respectively by wei
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For the current studies we used the selective Epac agonist
2020-04-03
For the current studies, we used the selective Epac agonist 8CPT-AM to directly activate the proteins. We chose this pharmacological approach since it allows a direct activation of Epacs rather than using receptor agonists such as PGE2 which could introduce confounding variables. One potential conce
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