• br Methods to assess cholesterol absorption br Methods of as

  2020-08-01

  

  Methods to assess cholesterol absorption Methods of assessment of cholesterol synthesis Cholesterol synthesis contributes substantially more to circulating cholesterol pools than cholesterol absorption, yielding approximately 700–900mg/day [24], [55]. This synthesis has been shown to undergo d

• br Role of ERK signaling in preventive and therapeutic poten

  2020-07-31

  

  Role of ERK signaling in preventive and therapeutic potential of flavonoids in neurodegenerative diseases ERK is one of the main pharmacological targets of natural phenolic compounds and contributes to several therapeutic approaches including anti-atherogenic, anti-cancer, anti-colitis, anti-arth

• br Conflict of interest br Acknowledgements We would like to

  2020-07-31

  

  Conflict of interest Acknowledgements We would like to thank Prof. Dr. Richard I. Dorin for helpful discussions on parameter values. This research was supported by funding from The Danish Society for the Protection of Laboratory Animals and from Alternativfondet. Methods Results Discu

• While the DDRs play important roles in embryo development as

  2020-07-31

  

  While the DDRs play important roles in ion channel development (as discussed in Section 5), their tissue functions in adults have not been established fully. Similarly, although we have some understanding of how dysregulated DDR function can lead to disease (discussed in Section 7), the normal func

• The two major families of E ubiquitin

  2020-07-31

  

  The two major SIN-1 chloride of E3 ubiquitin ligases (see Glossary) that coordinate cell division are SCFs (SKP1–CUL1–Fbox proteins), which were initially recognized for regulating interphase and are now known to control many stages of the cell cycle, and anaphase-promoting complex/cyclosome (APC/C

• br Conclusion Protein deubiquitination is becoming increasin

  2020-07-31

  

  Conclusion Protein deubiquitination is becoming increasingly instrumental in understanding the complexities of the Ub system. Adding to this complexity is the discovery of bacterial effectors with DUB activity that have structurally adapted themselves to interfere with the eukaryotic Ub system (P

• Small angle X ray scattering SAXS

  2020-07-31

  

  Small angle X-ray scattering (SAXS). Synchrotron SAXS measurements (I(s) vs s, where s = 4πsinθ/λ; 2θ is the scattering angle and λ = 0.125 nm) were performed at the EMBL-P12 bioSAXS beam line at the PETRA III storage ring (DESY, Hamburg) as described in Ref. [26] under continuous-flow batch mode op

• Interestingly from our consensus SBVC

  2020-07-31

  

  Interestingly, from our consensus SBVC protocol only few compounds (less than 150) have been scored with a full ‘ consensus’. That means that these compounds appear in the top 5% of the database when ranked by every scoring function independently. After visual inspection, we have realized that two a

• br Conclusions Recently Cohn advocated for a prospective stu

  2020-07-30

  

  Conclusions Recently, Cohn advocated for a prospective study to investigate the role of postprandial lipoproteins in cardiovascular disease (Cohn, 2008). However, he indicated that unlike LDL-cholesterol that can be easily modified by drugs, the levels of chylomicrons and their remnants are less

• br Testicular HSD B isoforms br HSD

  2020-07-30

  

  Testicular HSD3B isoforms HSD3B-inhibitory endocrine disruptors Many endocrine disruptors could be anti-androgens. One of their mechanisms is direct inhibition of testicular HSD3B activity [2,24]. These environmental endocrine disruptors are derived from food, environment and other consumer pr

• The binding of collagen X

  2020-07-30

  

  The binding of collagen X to DDR2 differs from the binding of collagen X to α2β1 integrin in that the triple helical conformation is essential for DDR2 binding. We previously reported that heat denatured pepsinised collagen X supported cell adhesion via α2β1, indicating that the triple-helical confo

• br Cyclin dependent kinases control

  2020-07-30

  

  Cyclin-dependent kinases control more than cell cycle CDKs’ roles conducting the concert of enzyme substrate was first revealed in the context of the tumor suppressor Rb, phosphorylation of which by CDK4 or CDK6 inactivates it loosing the transcription factor E2F [1], [12], [15]. Discovery of ot

• br Materials and methods br Acknowledgements We

  2020-07-30

  

  Materials and methods Acknowledgements We thank Drs. Nathan Sherer (University of Wisconsin-Madison) and Bryan Cullen (Duke University) for generous reagent gifts. The following reagent was obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: HIV-2ROD phage from Dr. Ron

• br Materials and methods br

  2020-07-30

  

  Materials and methods Results Discussion Intra-dPAG microinjections of CRF reduced open arm exploration without affecting general activity (closed-arm entries) in the EPM. This result corroborates previous studies demonstrating that intra-PAG CRF enhances anxiety-like indices in the EPM in

• Covalent binding of a drug to albumin

  2020-07-30

  

  Covalent binding of a drug to albumin can be achieved either through direct chemical conjugation or via the use of a small molecule to link the two components. Alternatively, it can be achieved through gene fusion to create a chimeric protein that is expressed in a suitable host, resulting in the pr

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