• All development in POE begins with the technical device

  2020-07-30

  

  All development in POE begins with the technical device that is the null problem, P. The null problem represents the existence of a problem of which no detail is known and forms the root of a development tree, such as that in Fig. 7. As mentioned above, ADD considers a problem, step rationale pair a

• Moreover RTn and dopamine D

  2020-07-29

  

  Moreover, RTn and dopamine D4-type receptors are associated with another\'s pathologies of the central nervous system, for example: multidisciplinary data suggests that a subcortical hyperdopaminergic condition is the key factor in the emergence of schizophrenia (Brisch et al., 2014, Durstewitz and

• The DDR gene is located in q and

  2020-07-29

  

  The DDR2 gene is located in 1q23.3, and its product is a tyrosine kinase receptor for fibrillar collagen [7], [8], [9], [10]. Under normal physiological conditions, it acts in cutaneous wound healing mediated by proliferation, chemotactic migration, and secretion of metalloproteinases and collagen b

• Of importance to the present investigation two studies Carva

  2020-07-29

  

  Of importance to the present investigation, two studies (Carvalho-Netto et al., 2007, Litvin et al., 2007) investigated the role played by CRF receptors of the dorsal periaqueductal gray (dPAG), which express both subtypes of CRF ligand sites (Merchenthaler, 1984, Swanson et al., 1983), in the regul

• Recently results obtained by our group have demonstrated

  2020-07-29

  

  Recently, results obtained by our group have demonstrated that hEECs are able to secrete NPY into the extracellular medium and that this peptide can induce an increase in the [Ca]i of these SR 11302 (Jacques et al., 2003b). In light of these results and those obtained in this study, we can speculat

• Malaria remains a major cause of

  2020-07-28

  

  Malaria remains a major cause of public health problem in about 95 countries mainly located in the tropical zone of the globe (notably Africa, South-East Asia and also Eastern Mediterranean region). This parasitic disease is still estimated to affect over 212 million people and accounted for 429,000

• CysLT receptors are expressed on a variety of peripheral

  2020-07-28

  

  CysLT receptors are expressed on a variety of peripheral blood leukocytes, but of interest, they are also expressed on cells that synthesize LTC, such as eosinophils and mast cells. The expression of cysLT receptors has not been evaluated on basophils, and efforts to do this have been hampered by th

• br Patients and methods br Results The study population cons

  2020-07-28

  

  Patients and methods Results The study Psalmotoxin 1 consisted of 96 children and adolescents. Thirty-nine subjects were girls and 57 were boys (Table 1). The mean age of the study population was 6.6 ± 0.5 (SE) years ranging from 0.10 to 15.94 years, and there was no difference between girls

• Progestogens include a broad range of steroids with progeste

  2020-07-28

  

  Progestogens include a broad range of steroids with progesterone-like actions, derived from different parent structures. So far, those used for contraception are structurally related to either testosterone (estranes and gonanes) or progesterone (pregnanes and 19-norpregnanes) (Schindler et al., 2003

• Expression of ERR ERR and PGC in

  2020-07-27

  

  Expression of ERRα, ERRγ and PGC-1α in metabolically active tissues such as skeletal muscle, heart and kidney has been reported by many laboratories (Bonnelye et al., 1997, Heard et al., 2000, Hong et al., 1999, Huss et al., 2002, Ichida et al., 2002, Knutti et al., 2000, Puigserver et al., 1998, Sa

• Besides collagen other cytoskeletal and or intracellular pro

  2020-07-27

  

  Besides collagen, other cytoskeletal and/or intracellular proteins could also have a putative role in modulating the spatial distribution and assembly of DDRs into clusters or filamentous structures. Our initial investigations to identify such proteins yielded limited success. Both DDR1b clusters as

• LPA is known to regulate the peroxisome

  2020-07-27

  

  LPA is known to regulate the peroxisome proliferator-activated receptor γ and the reorganization of actin cytoskeleton [58]. However, the physiological functions of LPA in cells are still poorly understood. The simultaneous production of PA with/without 1-LPA or 2-LPA may be important to maximize a

• br Materials and methods br Results To determine the

  2020-07-27

  

  Materials and methods Results To determine the effect of NAT1 deletion on mitochondrial function, OCR and ECAR were measured using a Seahorse XFe96 Flux Analyzer. In MDA-MB-231 cells, basal oxygen consumption, ATP-coupled oxygen consumption and reserve respiratory capacity decreased in the NAT

• br DDR receptor antagonism and osteoarthritis DDR is a

  2020-07-27

  

  DDR2 receptor antagonism and osteoarthritis DDR2 is a special kind of receptor that distinguished from other RTKs by discoid (DS) domain structurally of 162 amino-acid long motif in extracellular part. The reduction in the level ofDDR2 ion channels in mouse model is concerned with the delayed pro

• Vacuoles are also involved in senescence associated cellular

  2020-07-27

  

  Vacuoles are also involved in senescence-associated cellular degradation (Martínez et al., 2008). C13 (legumain-like) cysteine proteases, also called vacuolar processing erk pathway (VPEs) (Okamoto and Minamikawa, 1995), are involved in many vacuolar proteolytic processes (Diaz and Martinez, 2013;

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