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Additionally both in vitro and in vivo studies showed
2020-01-22
Additionally, both in vitro and in vivo studies showed that a Ca2+ influx is closely related to apoptosis (Rizzuto et al., 2003). Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells, which senses intracellular calcium levels by bindi
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In the previous study glutamyl endopeptidase of B intermediu
2020-01-22
In the previous study glutamyl endopeptidase of B. intermedius has been reported to be distributed in the UCM05 of B. intermedius as follows: 90% of synthesized enzyme has been detected in the culture liquid, 9.3% of glutamyl endopeptidase—in the fraction of membrane proteins [20]. The distribution
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br Acknowledgements This work was financially supported
2020-01-22
Acknowledgements This work was financially supported by Industrial Technology Institute, Sri Lanka through funds received from Sri Lankan Government Treasury (TG13/69). G. D. Liyanaarachchi received postgraduate research scholarship grant from National Science Foundation Sri Lanka (NSF/SCH/2017/0
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Our finding that activating DDR
2020-01-22
Our finding that activating DDR2 variants are a cause of this disease suggested that the ABL inhibitor dasatinib, a leukemia drug that also inhibits DDR2, could be used for treatment of affected individuals.10, 11 To examine the effect of dasatinib on p.Leu610Pro- and p.Tyr740Cys-induced autophospho
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Genomic DNA Isolation Kit Introduction Tumor necrosis factor
2020-01-22
Introduction Tumor necrosis factor (TNF) is a pro-inflammatory mediator with the capacity to induce apoptosis (Benderska et al., 2012). Recent reports have shown that TNF might trigger cell death, at least in part, by directly affecting the reorganization of the Genomic DNA Isolation Kit cytoskele
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br Conflicts of interest br Acknowledgements
2020-01-22
Conflicts of interest Acknowledgements This work was supported by funding from Young Sanjin Scholars Distinguished Professor, the Aid Program for Innovation Research Team in Shanxi Agricultural University (CXTD201201), and the Special Fund for Agro-scientific Research in the Public Interest of
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Acknowledgments br Prostaglandin D PGD plays a key
2020-01-22
Acknowledgments Prostaglandin D (PGD) plays a key role in mediating allergic reactions such as those seen in asthma, allergic rhinitis, atopic dermatitis and allergic conjunctivitis. PGD is the major cyclooxygenase product formed and secreted by activated mast cells and its levels in bronchoalveo
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Mohan et al found no improvement of the
2020-01-22
Mohan et al. [8] found no improvement of the strength of the bricks due to addition of waste RHA. Hossain et al. [9] collected RHA from a local rice mill, where rice husk was burnt in an uncontrolled environment, and then used for replacement of clay in brick production. With inclusion of RHA water
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We have previously shown that sustained pCPT treatment favor
2020-01-22
We have previously shown that sustained 8-pCPT treatment favored Ca2+-dependent arrhythmogenic activity in rat ventricular cardiomyocytes [8]. Fig. 2 shows line-scan Ca2+ images of myocyte incubated without (Fig. 2A left) and with 8-pCPT (Fig. 2A right) subjected to a train of electrical stimulation
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br Materials and methods br Results br Discussion Oxidative
2020-01-22
Materials and methods Results Discussion Oxidative stress is a disturbance in the balance of pro- and antioxidant species, resulting in oxidative damage to membrane proteins, lipids, and DNA. Oxidative stress is a predisposing factor for the progression of metabolic diseases and liver injur
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br Experimental br Acknowledgments The work was supported
2020-01-22
Experimental Acknowledgments The work was supported in part by the National Research and Development Plan (2017YFD0200506), the National Natural Science Foundation of China (21472062 and 31701820), 111 Project B17019, and excellent doctoral dissertation cultivation Grant from Central China Nor
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Compound was synthesized by the directed metallation
2020-01-22
Compound () was synthesized by the directed -metallation procedure (DOM) at the stage of the amide using butyl lithium and dry ice as CO source for the introduction of the carboxylic group. Thiophene amides were prepared from commercial 3-thiophenecarboxylic GSK503 by conversion into the acid chl
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Nitrocefin mg DDR plays a crucial role in regulating a wide
2020-01-21
DDR2 plays a crucial role in regulating a wide variety of fundamental cellular processes, including cell proliferation, differentiation, and adhesion [17], [28], [29], [30]. The authors revealed compromised cell migration in DDR2-silenced fibroblasts exposed to Ang II, most likely due to the loss of
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ERK and p MAPK signaling pathways play critical
2020-01-21
ERK and p38 MAPK signaling pathways play critical role in genesis and metastasis of melanoma (Tang et al., 2018). >50% of melanoma Betulinic Acid (Abildgaard and Guldberg, 2015) show abnormal activity of BRAF-RAS-RAF to activate MEK signal that drives the growth-promoting extracellular signal-regula
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Co operation or synergy between PKA and
2020-01-21
Co-operation or synergy between PKA and Epac has been recently reported in PCCL3 thyroid cell line in which cAMP is pro-mitogenic, in KN-93 to VSMC [19]. Our study demonstrates for the first time that PKA and Epac also synergise to inhibit cell proliferation in a cell type where cAMP in anti-mitoge
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