• Previous studies from our laboratory in CD mice using the

  2020-05-21

  

  Previous studies from our laboratory in CD1 mice using the incisional postoperative pain model have shown that the incision induces significant mechanical postoperative hyperalgesia lasting between 7 and 10days, with peak effect between 4h-2days (Cabañero et al., 2009a, Cabañero et al., 2009b, Campi

• The aim of this study was to use molecular methods

  2020-05-20

  

  The aim of this study was to use molecular methods to characterise C. difficile isolates circulating in the Czech Republic from 2013 to 2015. Material and methods Discussion During a three-year period (2013–2015) a total of 32 hospitals voluntarily participated in this project, but only 11 ho

• In frame exon skipping of COL A has

  2020-05-20

  

  In frame exon 41 skipping of COL6A3 has been suspected to be responsible for isolated dystonia in several human kindreds without muscular defects [94]. In order to validate their hypothesis, the authors used zebrafish to selectively knock down several exons in col6a3 and found a negative impact on m

• Methods br Results First we compared A plaque number A

  2020-05-20

  

  Methods Results First, we compared Aβ plaque number, Aβ concentration, and neurobehavior functions between naive APP/PS1 and APP/PS1xEP1−/− mice. Significantly lower Aβ burden in APP/PS1xEP1−/− mice was evidenced by fewer plaques in the hippocampal area and a lower concentration of soluble Aβ42

• The archaea are a group of microorganisms

  2020-05-20

  

  The archaea are a group of microorganisms, and many belong to extremophiles, living in extreme environments, such as those with high temperatures [6], [7]. Methanocaldococcus jannaschii is a methane-producing archaea [8]. It grows at pressures of up to more than 200atm and at an optimum temperature

• Collagen compaction and alignment are generated

  2020-05-20

  

  Collagen compaction and alignment are generated by cell-mediated contractile forces (Stopak and Harris, 1982). The transmission of actomyosin forces to collagen has been mainly attributed to integrins and the activation of the Rho-ROCK pathway (Clark et al., 2007, Kural and Billiar, 2013, Provenzano

• To overcome problems with the biochemical reconstitution of

  2020-05-20

  

  To overcome problems with the biochemical reconstitution of these heterodimeric cytokines fusion strategies linking both subunits together have been proposed inspired by the “hyper-IL-6” [28]. Much like fusing a protein to a solubility enhancing protein such as MBP or SUMO, fusing two subunits of a

• The effect of ET activity on the

  2020-05-19

  

  The effect of ET-1 activity on the development of experimental pulmonary fibrosis has also been examined by other investigators. One study found that repeated administration of Bosentan, an ERA used to treat pulmonary arterial hypertension (PAH), significantly decreased bleomycin-induced pulmonary f

• br Introduction Breast cancer is the most

  2020-05-18

  

  Introduction Breast cancer is the most common cancer in women and one of the leading causes of death worldwide. Estrogen receptor alpha (ERα, “wild-type” estrogen receptor), encoded by the estrogen receptor1 (ESR1) gene, is expressed in approximately 70% of all breast cancers. Hormonal therapy ha

• Introduction Psoriasis is a chronic recurrent and

  2020-05-18

  

  Introduction Psoriasis is a chronic, recurrent and inflammatory skin disease, and it is characterized by erythema, skin hyperplasia, scales, and hyperproliferation of keratinocyte [1]. It is reported that the psoriasis occurrences are about 3% worldwide [2], but the number varies depending on ethni

• br Conclusions We can conclude that Arg

  2020-05-18

  

  Conclusions We can conclude that Arg293 is important but not indispensable for MeGlcA recognition by EcXyn30A since the R293A variant still retains activity and preference for MeGlcA-substituted substrates. The substrate specificity of GH30_8 glucuronoxylanases is most probably determined by an o

• br No Evidence for Further ET Receptor

  2020-05-18

  

  No Evidence for Further ET-Receptor Subtypes Further receptor subclassifications have been proposed including suggestions that ETB could be subdivided into ETB1, present on endothelial cells, and ETB2 on smooth muscle cells, but there currently is no evidence that the receptors expressed by these

• br STAR Methods br Acknowledgments We are grateful

  2020-05-18

  

  STAR★Methods Acknowledgments We are grateful to Matthias Mayer at ZMBH in Heidelberg for access to his CD-spectrometer and his help in data interpretation. Technical support by Wolfgang Weinig is gratefully acknowledged. This project was financially supported by the European Union as part of t

• The current study provides evidence

  2020-05-18

  

  The current study provides evidence for a previously unknown role for DHODH as a growth/survival factor in KRAS mutant tumors. While many aspects of the link between DHODH inhibition and survival of KRAS mutant cells remain to be established, de novo pyrimidine biosynthesis appears to be a crucial p

• We note that there are slight qualitative differences among

  2020-05-18

  

  We note that there are slight qualitative differences among the similar time-optimal protocols. We attribute this to the challenging nature of our PDE and ODE state constrained optimization problem. While our optimization algorithm was able to converge to local optima in each case, it is likely that

15547 records 812/1037 page Previous Next First page 上5页 811812813814815 下5页 Last page