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In summary we developed a powerful
2018-11-08
In summary, we developed a powerful strategy generating hemangiogenic FLK-1+ progenitors from ESCs. The unlimited access to hemangioblasts, the ultimate hematopoietic and vascular progenitors, warrants further investigations on potential clinical applications requiring hematopoietic, vascular repair
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This is in accord with previous reports that astrocytes infl
2018-11-08
This is in accord with previous reports, that astrocytes influence both proliferation and differentiation of embryonic and adult neural stem cells, and specifically promote neurogenic fate of neural stem cells (Roy et al., 2006; Nakayama et al., 2003; Song et al., 2002). Factors that affect neural s
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BMSCs interfere with DC differentiation maturation and funct
2018-11-08
BMSCs interfere with DC differentiation, maturation and function. IL-6 was initially thought as the main effector in the inhibition of DC differentiation by BMSCs. Djouda et al. reported that murine MSCs secreted high level of IL-6, which down-regulates the expression of MHC II, CD40, and CD86 on ma
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D8-MMAE br Introduction In mammalian cells pluripotency is
2018-11-08
Introduction In mammalian cells, pluripotency is defined as the ability to self renew and to give rise to progenitors that differentiate into all cell types of the organism. This is best exemplified in the embryonic stem (ES) cells and D8-MMAE inner cell mass (ICM) cells that give rise to the e
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Environmental oxygen levels affect tissue
2018-11-08
Environmental oxygen levels affect tissue vascularization and fracture healing. A previous study suggested that hyperoxia (50% O2 and 1ATA) increased tissue vascularization but did not significantly alter osteogenesis during the early stages of fracture healing (Lu et al., 2013). Most of the inspire
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On the other hand a major advantage of
2018-11-08
On the other hand, a major advantage of this alternative double-reporter genetic model is to provide a clear-cut qualitative answer as to whether new CMs are formed after injury and if so, whether these new CMs originated predominantly from pre-existing CMs or from another cell population. If no new
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DNA methylation can be passively lost during
2018-11-08
DNA methylation can be passively lost during DNA replication if it is not maintained by DNA methyltransferases (Chen and Riggs, 2011; Li and Zhang, 2014; Moore et al., 2013; Ooi et al., 2009). Besides passive loss due to DNA replication during cell divisions, DNA methylation can also be subject to a
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In addition we also injected the neurospheres
2018-11-08
In addition, we also injected the neurospheres into SCID mouse brains. The confocal images showed that the AdSTEP-fragmented neurospheres had abundant PAX6-positive Phos-tag Biotin in the cerebral cortex (Fig. 6C) that contained larger NTTR structures, similar to those observed in vitro. These resu
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pkg inhibitor Mesenchymal stem cells MSCs can be isolated fr
2018-11-08
Mesenchymal stem pkg inhibitor (MSCs) can be isolated from various adult tissues (including bone marrow), they are multipotent and can differentiate into cells of the mesodermal (e.g. adipocytes, osteocytes, chondrocytes) as well as other embryonic lineages (Jiang et al., 2002). MSCs can also be cul
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br Materials and methods br Acknowledgments We
2018-11-08
Materials and methods Acknowledgments We would like to thank Ida Jørring and Anita Pacht for their excellent technical assistance. This project was funded by the European Union 7th Framework Program (PIAPP-GA-2012-324451-STEMMAD) and Innovation Fund Denmark through BrainStem. Resource table
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It has been hypothesized that
2018-11-08
It has been hypothesized that neurogenesis in DG may play an important role in learning and memory and especially in spatial memory (Deng et al., 2010; Jessberger et al., 2009; Piatti et al., 2013). In the present study, mice with AQ treatment showed an increased percentage of spontaneous alternatio
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SATB acts as a master regulator by binding to genes
2018-11-08
SATB2 acts as a master regulator by binding to genes which regulate embryonic development, cell differentiation, pluripotency, and cell survival (Ordonez, 2014; Rosenfeld et al., 2009; Zhao et al., 2014). We have discovered the SATB2 hcv virus in the promoters of c-Myc, Nanog, Kl4, Bcl-2 and XIAP ge
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Although our model supported viral
2018-11-08
Although our model supported viral life cycle, there were key elements of the system that required more detailed attention. Despite robust infection, hESC-Heps and primary hepatocytes produce less infectious virions than Huh7 line (Liang et al., 2009; Ploss et al., 2010; Podevin et al., 2010; Roelan
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In our previous studies Choi
2018-11-08
In our previous studies (Choi et al., 2012; Vodyanik et al., 2006, 2010), we identified distinct stages of hematoendothelial development following hPSC differentiation in coculture with OP9 (Figure 1). Plating hPSCs onto OP9 stromal Zebularine induces the formation of primitive streak and mesodermal
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Although we followed all of the
2018-11-08
Although we followed all of the rules, we hesitate to use the phrase cGMP-compliant because this is a determination that will ultimately be made by the regulatory authorities when the entire IND package is provided to the FDA. We also note that the approval of the use of this line as part of an IND
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